| http://purl.uniprot.org/citations/1431103 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1431103 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1431103 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-1 beta is a potent modulator of immune and inflammatory responses. Murine IL-1 beta is initially synthesized as an inactive 33-kDa pro-molecule that is activated by proteolytic cleavage between Asp-117 and Val-118 to generate the 17-kDa mature IL-1 beta protein. This cleavage is catalyzed by a specific protease that has been designated the IL-1 beta converting enzyme (or IL-1 beta convertase). We have used a human IL-1 beta convertase cDNA to isolate murine convertase cDNA from a WEHI-3 library. These cDNA predicted that the murine convertase is a 402-residue protein. Overall, the murine convertase showed 71% nucleotide and 62% predicted amino acid sequence identity with the human convertase. Southern blot analysis of interspecific backcross mice indicated that the murine IL-1 beta convertase is encoded by a single copy gene located on murine chromosome 9. The murine convertase showed broad constitutive expression, being detected in mononuclear phagocyte and T lymphocyte cell lines as well as in spleen, heart, brain, and adrenal glands. The expression of the murine convertase in mononuclear phagocytes was up-regulated by treatment with LPS or rIFN-gamma. These studies establish that the IL-1 beta convertase is an evolutionarily conserved, widely expressed enzyme that can be regulated at a pretranslational level."xsd:string |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/author | "Copeland N.G."xsd:string |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/author | "Copeland N.G."xsd:string |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/author | "Gilbert D.J."xsd:string |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/author | "Gilbert D.J."xsd:string |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/author | "Jenkins N.A."xsd:string |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/author | "Jenkins N.A."xsd:string |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/author | "Black R.A."xsd:string |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/author | "Black R.A."xsd:string |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/author | "Cerretti D.P."xsd:string |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/author | "Cerretti D.P."xsd:string |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/author | "Chaplin D.D."xsd:string |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/author | "Chaplin D.D."xsd:string |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/author | "Berson D.R."xsd:string |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/author | "Berson D.R."xsd:string |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/author | "Nett-Fiordalisi M.A."xsd:string |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/author | "Nett-Fiordalisi M.A."xsd:string |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/pages | "3254-3259"xsd:string |
| http://purl.uniprot.org/citations/1431103 | http://purl.uniprot.org/core/pages | "3254-3259"xsd:string |