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http://purl.uniprot.org/citations/1436033http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1436033http://www.w3.org/2000/01/rdf-schema#comment"Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional growth factor that has profound regulatory effects on many developmental and physiological processes. Disruption of the TGF-beta 1 gene by homologous recombination in murine embryonic stem cells enables mice to be generated that carry the disrupted allele. Animals homozygous for the mutated TGF-beta 1 allele show no gross developmental abnormalities, but about 20 days after birth they succumb to a wasting syndrome accompanied by a multifocal, mixed inflammatory cell response and tissue necrosis, leading to organ failure and death. TGF-beta 1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions."xsd:string
http://purl.uniprot.org/citations/1436033http://purl.org/dc/terms/identifier"doi:10.1038/359693a0"xsd:string
http://purl.uniprot.org/citations/1436033http://purl.uniprot.org/core/author"Allen R."xsd:string
http://purl.uniprot.org/citations/1436033http://purl.uniprot.org/core/author"Yin M."xsd:string
http://purl.uniprot.org/citations/1436033http://purl.uniprot.org/core/author"Shull M.M."xsd:string
http://purl.uniprot.org/citations/1436033http://purl.uniprot.org/core/author"Diebold R.J."xsd:string
http://purl.uniprot.org/citations/1436033http://purl.uniprot.org/core/author"Proetzel G."xsd:string
http://purl.uniprot.org/citations/1436033http://purl.uniprot.org/core/author"Kier A.B."xsd:string
http://purl.uniprot.org/citations/1436033http://purl.uniprot.org/core/author"Pawlowski S."xsd:string
http://purl.uniprot.org/citations/1436033http://purl.uniprot.org/core/author"Calvin D."xsd:string
http://purl.uniprot.org/citations/1436033http://purl.uniprot.org/core/author"Ormsby I."xsd:string
http://purl.uniprot.org/citations/1436033http://purl.uniprot.org/core/author"Sidman C."xsd:string
http://purl.uniprot.org/citations/1436033http://purl.uniprot.org/core/date"1992"xsd:gYear
http://purl.uniprot.org/citations/1436033http://purl.uniprot.org/core/name"Nature"xsd:string
http://purl.uniprot.org/citations/1436033http://purl.uniprot.org/core/pages"693-699"xsd:string
http://purl.uniprot.org/citations/1436033http://purl.uniprot.org/core/title"Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease."xsd:string
http://purl.uniprot.org/citations/1436033http://purl.uniprot.org/core/volume"359"xsd:string
http://purl.uniprot.org/citations/1436033http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/1436033
http://purl.uniprot.org/citations/1436033http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/1436033
http://purl.uniprot.org/citations/1436033http://purl.uniprot.org/core/authorsIncomplete"true"xsd:boolean
http://purl.uniprot.org/uniprot/P04202#attribution-67FF1BBFB163D8D618A1797891D336B6http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/1436033
http://purl.uniprot.org/uniprot/P04202#attribution-D5B78462F8807EA82AA29B9FD4511808http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/1436033
http://purl.uniprot.org/uniprot/#_E9Q8Y5-mappedCitation-1436033http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/1436033
http://purl.uniprot.org/uniprot/#_E9Q9B8-mappedCitation-1436033http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/1436033