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http://purl.uniprot.org/citations/1436033 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional growth factor that has profound regulatory effects on many developmental and physiological processes. Disruption of the TGF-beta 1 gene by homologous recombination in murine embryonic stem cells enables mice to be generated that carry the disrupted allele. Animals homozygous for the mutated TGF-beta 1 allele show no gross developmental abnormalities, but about 20 days after birth they succumb to a wasting syndrome accompanied by a multifocal, mixed inflammatory cell response and tissue necrosis, leading to organ failure and death. TGF-beta 1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions."xsd:string |
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http://purl.uniprot.org/citations/1436033 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
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http://purl.uniprot.org/citations/1436033 | http://purl.uniprot.org/core/title | "Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease."xsd:string |
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