| http://purl.uniprot.org/citations/1445376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1445376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1445376 | http://www.w3.org/2000/01/rdf-schema#comment | "We isolated and expressed a clone, hPA6, possibly corresponding to the CYP2C9 cDNA. Compared with the other CYP2C9 cDNA clones, hPA6 showed a 6-nucleotide deletion near its middle. From the same cDNA library, we could also isolate another cDNA clone, named hPA22, which retained the 6 bases. For clarification of the effect of the 2-amino acid deletion resulting from the 6-base deletion on enzymatic activities, both clones were expressed in yeast. The expressed enzymes showed tolbutamide hydroxylase activities, and these activities were inhibited by antibodies against P-450-HM2, a probable CYP2C9. The activity of the enzyme encoded by hPA6 was lower than that encoded by hPA22; thus the 2-amino acid deletion in the CYP2C9 reduced the enzymatic activity."xsd:string |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/author | "Ohgiya S."xsd:string |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/author | "Ohgiya S."xsd:string |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/author | "Kamataki T."xsd:string |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/author | "Kamataki T."xsd:string |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/author | "Ohi H."xsd:string |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/author | "Ohi H."xsd:string |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/author | "Komori M."xsd:string |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/author | "Komori M."xsd:string |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/author | "Shinriki N."xsd:string |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/author | "Shinriki N."xsd:string |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/author | "Shiramatsu K."xsd:string |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/author | "Shiramatsu K."xsd:string |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/name | "Biochem. Int."xsd:string |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/name | "Biochem. Int."xsd:string |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/pages | "1073-1081"xsd:string |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/pages | "1073-1081"xsd:string |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/title | "Six-base deletion occurring in messages of human cytochrome P-450 in the CYP2C subfamily results in reduction of tolbutamide hydroxylase activity."xsd:string |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/title | "Six-base deletion occurring in messages of human cytochrome P-450 in the CYP2C subfamily results in reduction of tolbutamide hydroxylase activity."xsd:string |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/1445376 | http://purl.uniprot.org/core/volume | "27"xsd:string |