| http://purl.uniprot.org/citations/1448154 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1448154 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1448154 | http://www.w3.org/2000/01/rdf-schema#comment | "Infection by influenza virus results in the stimulation of cytotoxic T lymphocytes specific for killing virally infected cells. Specificity is provided by clonally distributed, hypervariable T-cell receptors on cytotoxic T lymphocytes which react with peptide fragments that are derived from viral proteins expressed in the cytoplasm and 'presented' on the surface of infected cells, bound to class I histocompatibility glycoproteins. Here we describe the structure of the complex between the human class I histocompatibility glycoprotein HLA-Aw68 and the influenza virus nucleoprotein peptide Np 91-99 as determined by X-ray cryocrystallography. Residues at both ends of the peptide are substantially buried in the peptide binding-site, whereas those in the middle of the peptide, P4 to P8, are predominantly exposed and could be recognized directly by T-cell receptors. The extended conformation of the bound viral peptide is remarkably similar to that of a collection of endogenous peptides with a different sequence motif bound to another human allele, HLA-B27. The structure defines in atomic detail the antigenic surface constructed of major histocompatibility complex and viral peptide atoms that is recognized by T-cell receptors."xsd:string |
| http://purl.uniprot.org/citations/1448154 | http://purl.org/dc/terms/identifier | "doi:10.1038/360367a0"xsd:string |
| http://purl.uniprot.org/citations/1448154 | http://purl.org/dc/terms/identifier | "doi:10.1038/360367a0"xsd:string |
| http://purl.uniprot.org/citations/1448154 | http://purl.uniprot.org/core/author | "Strominger J.L."xsd:string |
| http://purl.uniprot.org/citations/1448154 | http://purl.uniprot.org/core/author | "Strominger J.L."xsd:string |
| http://purl.uniprot.org/citations/1448154 | http://purl.uniprot.org/core/author | "Wiley D.C."xsd:string |
| http://purl.uniprot.org/citations/1448154 | http://purl.uniprot.org/core/author | "Wiley D.C."xsd:string |
| http://purl.uniprot.org/citations/1448154 | http://purl.uniprot.org/core/author | "Guo H.-C."xsd:string |
| http://purl.uniprot.org/citations/1448154 | http://purl.uniprot.org/core/author | "Guo H.-C."xsd:string |
| http://purl.uniprot.org/citations/1448154 | http://purl.uniprot.org/core/author | "Silver M.L."xsd:string |
| http://purl.uniprot.org/citations/1448154 | http://purl.uniprot.org/core/author | "Silver M.L."xsd:string |
| http://purl.uniprot.org/citations/1448154 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1448154 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1448154 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/1448154 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/1448154 | http://purl.uniprot.org/core/pages | "367-369"xsd:string |
| http://purl.uniprot.org/citations/1448154 | http://purl.uniprot.org/core/pages | "367-369"xsd:string |
| http://purl.uniprot.org/citations/1448154 | http://purl.uniprot.org/core/title | "Atomic structure of a human MHC molecule presenting an influenza virus peptide."xsd:string |
| http://purl.uniprot.org/citations/1448154 | http://purl.uniprot.org/core/title | "Atomic structure of a human MHC molecule presenting an influenza virus peptide."xsd:string |
| http://purl.uniprot.org/citations/1448154 | http://purl.uniprot.org/core/volume | "360"xsd:string |
| http://purl.uniprot.org/citations/1448154 | http://purl.uniprot.org/core/volume | "360"xsd:string |
| http://purl.uniprot.org/citations/1448154 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1448154 |
| http://purl.uniprot.org/citations/1448154 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1448154 |