| http://purl.uniprot.org/citations/14499357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14499357 | http://www.w3.org/2000/01/rdf-schema#comment | "Osteoporosis, a multifactorial common disease, is believed to result from the interplay of multiple environmental and genetic factors that regulate bone mineral density (BMD). Tumor necrosis factor receptor associated factor-interacting protein (I-TRAF) is an essential effecter of the tumor necrosis factor receptor-signaling cascade, one of the most potent bone-resorbing systems. In genetic studies of 382 Japanese adult women, we found that genotypes of two promoter variations of I-TRAF gene, -1542T/G and -525G/C, were similarly associated with radial BMD levels. Two variations were in almost complete linkage disequilibrium (D' = 0.978, r(2) = 0.917, chi(2) = 695, 2, P = 3.4 x 10(-153)), and there were two exclusive haplotypes (-1542T/-525C, frequency 0.74, and -1542G/-525G, frequency 0.24) among our test subjects. When BMD values were compared among the three haplotypic categories (-1542G/-525G homozygotes, heterozygotes, and -1542T/-525C homozygotes), BMD was lowest among -1542G/-525C homozygotes (mean +/- SD = 0.382 +/-0.060 g/cm(2)), highest among -1542T/-525G homozygotes (0.405 +/-0.051 g/cm(2)), and intermediate among heterozygotes (0.395 +/-0.056 g/cm(2)) (r = 0.11, P = 0.030). The observed trend supported a codominant effect of the relevant haplotype of I-TRAF gene in determination of radial BMD. These results suggested that variation of I-TRAF might be an important determinant for postmenopausal osteoporosis."xsd:string |
| http://purl.uniprot.org/citations/14499357 | http://purl.org/dc/terms/identifier | "doi:10.1016/s8756-3282(03)00226-6"xsd:string |
| http://purl.uniprot.org/citations/14499357 | http://purl.uniprot.org/core/author | "Ito H."xsd:string |
| http://purl.uniprot.org/citations/14499357 | http://purl.uniprot.org/core/author | "Inoue S."xsd:string |
| http://purl.uniprot.org/citations/14499357 | http://purl.uniprot.org/core/author | "Suzuki T."xsd:string |
| http://purl.uniprot.org/citations/14499357 | http://purl.uniprot.org/core/author | "Yoshida H."xsd:string |
| http://purl.uniprot.org/citations/14499357 | http://purl.uniprot.org/core/author | "Emi M."xsd:string |
| http://purl.uniprot.org/citations/14499357 | http://purl.uniprot.org/core/author | "Kajita M."xsd:string |
| http://purl.uniprot.org/citations/14499357 | http://purl.uniprot.org/core/author | "Shiraki M."xsd:string |
| http://purl.uniprot.org/citations/14499357 | http://purl.uniprot.org/core/author | "Ezura Y."xsd:string |
| http://purl.uniprot.org/citations/14499357 | http://purl.uniprot.org/core/author | "Ishida R."xsd:string |
| http://purl.uniprot.org/citations/14499357 | http://purl.uniprot.org/core/author | "Hosoi T."xsd:string |
| http://purl.uniprot.org/citations/14499357 | http://purl.uniprot.org/core/author | "Orimo H."xsd:string |
| http://purl.uniprot.org/citations/14499357 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14499357 | http://purl.uniprot.org/core/name | "Bone"xsd:string |
| http://purl.uniprot.org/citations/14499357 | http://purl.uniprot.org/core/pages | "237-241"xsd:string |
| http://purl.uniprot.org/citations/14499357 | http://purl.uniprot.org/core/title | "Association of a promoter haplotype (-1542G/-525C) in the tumor necrosis factor receptor associated factor-interacting protein gene with low bone mineral density in Japanese women."xsd:string |
| http://purl.uniprot.org/citations/14499357 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/14499357 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14499357 |
| http://purl.uniprot.org/citations/14499357 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14499357 |
| http://purl.uniprot.org/uniprot/#_B2R7S3-mappedCitation-14499357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14499357 |
| http://purl.uniprot.org/uniprot/#_Q53TI5-mappedCitation-14499357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14499357 |
| http://purl.uniprot.org/uniprot/#_Q4ZG76-mappedCitation-14499357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14499357 |
| http://purl.uniprot.org/uniprot/#_Q6NW12-mappedCitation-14499357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14499357 |