| http://purl.uniprot.org/citations/14499478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14499478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14499478 | http://www.w3.org/2000/01/rdf-schema#comment | "p190RhoGEF is a large multi-functional protein with guanine nucleotide exchange (GEF) activity. The C-terminal region of p190RhoGEF is a highly interactive domain that binds multiple factors, including proteins with anti-apoptotic activities. We now report that transfection of EGFP-tagged p190RhoGEF protects Neuro 2a cells from stress-induced apoptosis and that anti-apoptotic activity is localized to cytoplasmic retention sequences (CRS-1 and CRS-2) in the C-terminal region of p190RhoGEF. Cytoplasmic retention is conferred to an EGFP fluorescent marker when fused to either CRS-1 or CRS-2. Both cytoplasmic retention and anti-apoptotic activity are lost by deleting CRS-1 and CRS-2 in the p190RhoGEF sequence and can be recovered by restoring either CRS-1 or CRS-2 to the EGFP-tagged sequence. Since the CRS-1 and CRS-2 contain the JIP-1 and 14-3-3 binding sites, we propose that anti-apoptotic activity may be conferred by the binding of p190RhoGEF to JIP-1 or 14-3-3, possibly by altering their interactive properties or nucleocytoplasmic movements. Taken together, our findings support a model whereby multiple interactions of p190RhoGEF confer homeostatic properties to differentiated neurons and may link neuronal homeostasis to the regulation of NF-L expression."xsd:string |
| http://purl.uniprot.org/citations/14499478 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0169-328x(03)00263-8"xsd:string |
| http://purl.uniprot.org/citations/14499478 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0169-328x(03)00263-8"xsd:string |
| http://purl.uniprot.org/citations/14499478 | http://purl.uniprot.org/core/author | "Canete-Soler R."xsd:string |
| http://purl.uniprot.org/citations/14499478 | http://purl.uniprot.org/core/author | "Canete-Soler R."xsd:string |
| http://purl.uniprot.org/citations/14499478 | http://purl.uniprot.org/core/author | "Lin H."xsd:string |
| http://purl.uniprot.org/citations/14499478 | http://purl.uniprot.org/core/author | "Lin H."xsd:string |
| http://purl.uniprot.org/citations/14499478 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/14499478 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/14499478 | http://purl.uniprot.org/core/author | "Schlaepfer W.W."xsd:string |
| http://purl.uniprot.org/citations/14499478 | http://purl.uniprot.org/core/author | "Schlaepfer W.W."xsd:string |
| http://purl.uniprot.org/citations/14499478 | http://purl.uniprot.org/core/author | "Zhai J."xsd:string |
| http://purl.uniprot.org/citations/14499478 | http://purl.uniprot.org/core/author | "Zhai J."xsd:string |
| http://purl.uniprot.org/citations/14499478 | http://purl.uniprot.org/core/author | "Nie Z."xsd:string |
| http://purl.uniprot.org/citations/14499478 | http://purl.uniprot.org/core/author | "Nie Z."xsd:string |
| http://purl.uniprot.org/citations/14499478 | http://purl.uniprot.org/core/author | "Garcia-Bermejo L."xsd:string |
| http://purl.uniprot.org/citations/14499478 | http://purl.uniprot.org/core/author | "Garcia-Bermejo L."xsd:string |
| http://purl.uniprot.org/citations/14499478 | http://purl.uniprot.org/core/author | "Ge W.-W."xsd:string |
| http://purl.uniprot.org/citations/14499478 | http://purl.uniprot.org/core/author | "Ge W.-W."xsd:string |
| http://purl.uniprot.org/citations/14499478 | http://purl.uniprot.org/core/author | "Muschel R.J."xsd:string |
| http://purl.uniprot.org/citations/14499478 | http://purl.uniprot.org/core/author | "Muschel R.J."xsd:string |
| http://purl.uniprot.org/citations/14499478 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14499478 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |