| http://purl.uniprot.org/citations/14500336 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14500336 | http://www.w3.org/2000/01/rdf-schema#comment | "Myosin binding protein-C (MyBP-C) is localized to the thick filaments of striated muscle where it appears to have both structural and regulatory functions. Importantly, mutations in the cardiac MyBP-C gene are associated with familial hypertrophic cardiomyopathy. The purpose of this study was to examine the role that MyBP-C plays in regulating force, power output, and force development rates in cardiac myocytes. Skinned cardiac myocytes from wild-type (WT) and MyBP-C knockout (MyBP-C-/-) mice were attached between a force transducer and position motor. Force, loaded shortening velocities, and rates of force redevelopment were measured during both maximal and half-maximal Ca2+ activations. Isometric force was not different between the two groups with force being 17.0+/-7.2 and 20.5+/-3.1 kN/m2 in wild-type and MyBP-C-/-myocytes, respectively. Peak normalized power output was significantly increased by 26% in MyBP-C-/-myocytes (0.15+/-0.01 versus 0.19+/-0.03 P/Po x ML/sec) during maximal Ca2+ activations. Interestingly, peak power output in MyBP-C-/-myocytes was increased to an even greater extent (46%, 0.09+/-0.03 versus 0.14+/-0.02 P/Po x ML/sec) during half-maximal Ca2+ activations. There was also an effect on the rate constant of force redevelopment (ktr) during half-maximal Ca2+ activations, with ktr being significantly greater in MyBP-C-/-myocytes (WT=5.8+/-0.9 s(-1) versus MyBP-C-/-=7.7+/-1.7 s(-1)). These results suggest that cMyBP-C is an important regulator of myocardial work capacity whereby MyBP-C acts to limit power output."xsd:string |
| http://purl.uniprot.org/citations/14500336 | http://purl.org/dc/terms/identifier | "doi:10.1161/01.res.0000096363.85588.9a"xsd:string |
| http://purl.uniprot.org/citations/14500336 | http://purl.uniprot.org/core/author | "Moss R.L."xsd:string |
| http://purl.uniprot.org/citations/14500336 | http://purl.uniprot.org/core/author | "McDonald K.S."xsd:string |
| http://purl.uniprot.org/citations/14500336 | http://purl.uniprot.org/core/author | "Harris S.P."xsd:string |
| http://purl.uniprot.org/citations/14500336 | http://purl.uniprot.org/core/author | "Korte F.S."xsd:string |
| http://purl.uniprot.org/citations/14500336 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14500336 | http://purl.uniprot.org/core/name | "Circ Res"xsd:string |
| http://purl.uniprot.org/citations/14500336 | http://purl.uniprot.org/core/pages | "752-758"xsd:string |
| http://purl.uniprot.org/citations/14500336 | http://purl.uniprot.org/core/title | "Loaded shortening, power output, and rate of force redevelopment are increased with knockout of cardiac myosin binding protein-C."xsd:string |
| http://purl.uniprot.org/citations/14500336 | http://purl.uniprot.org/core/volume | "93"xsd:string |
| http://purl.uniprot.org/citations/14500336 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14500336 |
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