| http://purl.uniprot.org/citations/14500364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14500364 | http://www.w3.org/2000/01/rdf-schema#comment | "A cryptic chromosome rearrangement, t(5;14)(q35.1;q32.2), recently identified in pediatric acute lymphoblastic leukemia (ALL), targets activation of TLX3 at 5q35.1 by juxtaposition with a region downstream of BCL11B at 14q32.2. We describe a novel variant t(5;14) whereby NKX2-5, a related (NK-like family) homeobox gene located approximately 2 Mb telomeric of TLX3, juxtaposes BCL11B in a subset of T-cell ALL cell lines. In this t(5;14) variant, NKX2-5 is expressed instead of TLX3 at both RNA and protein levels. Subsequent expression screening failed to detect involvement of additional NK-like genes in T-cell ALL cells. Our data pinpoint a regulatory region far downstream of BCL11B effecting ectopic homeobox gene activation. This study also identifies in vitro models for both t(5;14) variants and raises questions about diagnostic fluorescence in situ hybridization/reverse transcription-PCR screening in ALL."xsd:string |
| http://purl.uniprot.org/citations/14500364 | http://purl.uniprot.org/core/author | "Kaufmann M."xsd:string |
| http://purl.uniprot.org/citations/14500364 | http://purl.uniprot.org/core/author | "Drexler H.G."xsd:string |
| http://purl.uniprot.org/citations/14500364 | http://purl.uniprot.org/core/author | "MacLeod R.A."xsd:string |
| http://purl.uniprot.org/citations/14500364 | http://purl.uniprot.org/core/author | "Nagel S."xsd:string |
| http://purl.uniprot.org/citations/14500364 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14500364 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/14500364 | http://purl.uniprot.org/core/pages | "5329-5334"xsd:string |
| http://purl.uniprot.org/citations/14500364 | http://purl.uniprot.org/core/title | "The cardiac homeobox gene NKX2-5 is deregulated by juxtaposition with BCL11B in pediatric T-ALL cell lines via a novel t(5;14)(q35.1;q32.2)."xsd:string |
| http://purl.uniprot.org/citations/14500364 | http://purl.uniprot.org/core/volume | "63"xsd:string |
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