| http://purl.uniprot.org/citations/14500633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14500633 | http://www.w3.org/2000/01/rdf-schema#comment | "TCR ligation by the self-peptide-associated MHC molecules is essential for T cell development in the thymus, so that class II MHC-deficient mice do not generate CD4(+)CD8(-) T cells. The present results show that the administration of anti-TCR mAb into class II MHC-deficient mice restores the generation of CD4(+)CD8(-) T cells in vivo. The CD4 T cells were recovered in the thymus, peripheral blood, and the spleen, indicating that the anti-TCR treatment is sufficient for peripheral supply of newly generated CD4 T cells. Unlike peripheral CD4 T cells that disappeared within 5 wk after the treatment, CD4(+)CD8(-) thymocytes remained undiminished even after 5 wk, suggesting that CD4 T cells in the thymus are maintained separately from circulating CD4 T cells and even without class II MHC molecules. It was also found that the mass of medullary region in the thymus, which was reduced in class II MHC-deficient mice, was restored by the anti-TCR administration, suggesting that the medulla for CD4(+)CD8(-) thymocytes is formed independently of the medulla for CD4(-)CD8(+) thymocytes. These results indicate that in vivo anti-TCR treatment in class II MHC-deficient mice restores the generation of circulating CD4 T cells and optimal formation of the medulla in the thymus, suggesting that anti-TCR Ab may be useful for clinical treatment of class II MHC deficiencies."xsd:string |
| http://purl.uniprot.org/citations/14500633 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.171.7.3394"xsd:string |
| http://purl.uniprot.org/citations/14500633 | http://purl.uniprot.org/core/author | "Ueno T."xsd:string |
| http://purl.uniprot.org/citations/14500633 | http://purl.uniprot.org/core/author | "Takahama Y."xsd:string |
| http://purl.uniprot.org/citations/14500633 | http://purl.uniprot.org/core/author | "Saito F."xsd:string |
| http://purl.uniprot.org/citations/14500633 | http://purl.uniprot.org/core/author | "Nasreen M."xsd:string |
| http://purl.uniprot.org/citations/14500633 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14500633 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/14500633 | http://purl.uniprot.org/core/pages | "3394-3400"xsd:string |
| http://purl.uniprot.org/citations/14500633 | http://purl.uniprot.org/core/title | "In vivo treatment of class II MHC-deficient mice with anti-TCR antibody restores the generation of circulating CD4 T cells and optimal architecture of thymic medulla."xsd:string |
| http://purl.uniprot.org/citations/14500633 | http://purl.uniprot.org/core/volume | "171"xsd:string |
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