| http://purl.uniprot.org/citations/14500638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14500638 | http://www.w3.org/2000/01/rdf-schema#comment | "A population of CD25(+)CD4(+) regulatory T cells (T regs) functions to maintain immunological self tolerance by inhibiting autoreactive T cell responses. CD25(+)CD4(+) T regs are present in low, but steady, numbers in the peripheral lymphoid tissues of healthy mice. Recent studies have shown that IL-2 is an essential growth factor for these cells. How this cytokine functions to regulate CD25(+)CD4(+) T reg homeostasis and prevent autoimmune disease remains unknown. In conventional CD4(+) T cells, IL-2 triggers signaling pathways that promote proliferation and survival by activating the STAT5 transcription factor and by increasing the expression of the antiapoptotic protein, Bcl-2. We show here that bcl-2 deficiency does not affect CD25(+)CD4(+) T reg homeostasis, and that ectopic expression of this molecule fails to rescue CD25(+)CD4(+) T reg numbers or to prevent the development of autoimmunity in IL-2-deficient mice. Furthermore, transient activation of STAT5 is sufficient to increase CD25(+)CD4(+) T reg numbers in IL-2-deficient mice. Our study uncovers an essential role for STAT5 in maintaining CD25(+)CD4(+) T reg homeostasis and self-tolerance."xsd:string |
| http://purl.uniprot.org/citations/14500638 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.171.7.3435"xsd:string |
| http://purl.uniprot.org/citations/14500638 | http://purl.uniprot.org/core/author | "Baltimore D."xsd:string |
| http://purl.uniprot.org/citations/14500638 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/14500638 | http://purl.uniprot.org/core/author | "Vig M."xsd:string |
| http://purl.uniprot.org/citations/14500638 | http://purl.uniprot.org/core/author | "Van Parijs L."xsd:string |
| http://purl.uniprot.org/citations/14500638 | http://purl.uniprot.org/core/author | "Antov A."xsd:string |
| http://purl.uniprot.org/citations/14500638 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14500638 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/14500638 | http://purl.uniprot.org/core/pages | "3435-3441"xsd:string |
| http://purl.uniprot.org/citations/14500638 | http://purl.uniprot.org/core/title | "Essential role for STAT5 signaling in CD25+CD4+ regulatory T cell homeostasis and the maintenance of self-tolerance."xsd:string |
| http://purl.uniprot.org/citations/14500638 | http://purl.uniprot.org/core/volume | "171"xsd:string |
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