| http://purl.uniprot.org/citations/14500699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14500699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14500699 | http://www.w3.org/2000/01/rdf-schema#comment | "The complex interplay between cells and extracellular matrix (ECM) proteins is critical for lung development. Integrins are key modulators of this interaction. The integrin subunit alpha 8 associates with the beta(1)-subunit to form an RGD-binding integrin. We previously showed that, in adult lung, alpha 8 is expressed in contractile interstitial cells and smooth muscle cells and is upregulated in lung injury. To gain insight into the function of alpha 8 during lung development, we examined the spatiotemporal expression of alpha 8 throughout murine lung development. We compared the distribution of alpha 8 with alpha-smooth muscle actin (alpha SMA), fibronectin (alpha 8 ligand), and cytokeratin. alpha 8 co-localized with alpha SMA and fibronectin in the peribronchial and perivascular regions. In all stages, alpha 8 immunoreactivity was detected diffusely in the mesenchyme except for cells surrounding distal, newly forming airways. alpha 8, alpha SMA, and fibronectin co-localized at tips of secondary septae in the alveolar stage. We conclude that alpha 8 is marker for lung mesenchymal cells starting early in development. alpha 8 is also a marker for smooth muscle cells, expressed as early as alpha SMA. Co-localization of alpha 8 with fibronectin suggests a role in branching morphogenesis. Furthermore, alpha 8 may participate in secondary septation by modulating signals from the extracellular matrix to alveolar myofibroblasts."xsd:string |
| http://purl.uniprot.org/citations/14500699 | http://purl.org/dc/terms/identifier | "doi:10.1177/002215540305101008"xsd:string |
| http://purl.uniprot.org/citations/14500699 | http://purl.org/dc/terms/identifier | "doi:10.1177/002215540305101008"xsd:string |
| http://purl.uniprot.org/citations/14500699 | http://purl.uniprot.org/core/author | "Frevert C.W."xsd:string |
| http://purl.uniprot.org/citations/14500699 | http://purl.uniprot.org/core/author | "Frevert C.W."xsd:string |
| http://purl.uniprot.org/citations/14500699 | http://purl.uniprot.org/core/author | "Herzog E.L."xsd:string |
| http://purl.uniprot.org/citations/14500699 | http://purl.uniprot.org/core/author | "Herzog E.L."xsd:string |
| http://purl.uniprot.org/citations/14500699 | http://purl.uniprot.org/core/author | "Schnapp L.M."xsd:string |
| http://purl.uniprot.org/citations/14500699 | http://purl.uniprot.org/core/author | "Schnapp L.M."xsd:string |
| http://purl.uniprot.org/citations/14500699 | http://purl.uniprot.org/core/author | "Wagner T.E."xsd:string |
| http://purl.uniprot.org/citations/14500699 | http://purl.uniprot.org/core/author | "Wagner T.E."xsd:string |
| http://purl.uniprot.org/citations/14500699 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14500699 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14500699 | http://purl.uniprot.org/core/name | "J. Histochem. Cytochem."xsd:string |
| http://purl.uniprot.org/citations/14500699 | http://purl.uniprot.org/core/name | "J. Histochem. Cytochem."xsd:string |
| http://purl.uniprot.org/citations/14500699 | http://purl.uniprot.org/core/pages | "1307-1315"xsd:string |
| http://purl.uniprot.org/citations/14500699 | http://purl.uniprot.org/core/pages | "1307-1315"xsd:string |
| http://purl.uniprot.org/citations/14500699 | http://purl.uniprot.org/core/title | "Expression of the integrin subunit alpha8 in murine lung development."xsd:string |
| http://purl.uniprot.org/citations/14500699 | http://purl.uniprot.org/core/title | "Expression of the integrin subunit alpha8 in murine lung development."xsd:string |
| http://purl.uniprot.org/citations/14500699 | http://purl.uniprot.org/core/volume | "51"xsd:string |
| http://purl.uniprot.org/citations/14500699 | http://purl.uniprot.org/core/volume | "51"xsd:string |
| http://purl.uniprot.org/citations/14500699 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14500699 |
| http://purl.uniprot.org/citations/14500699 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14500699 |