| http://purl.uniprot.org/citations/14504110 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14504110 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14504110 | http://www.w3.org/2000/01/rdf-schema#comment | "In a series of 153 children with T-cell malignancies enrolled in 2 consecutive European Organization for Research and Treatment of Cancer (EORTC) trials, we assessed the HOX11L2 expression and/or the presence of a t(5;14)(q35;q32). Additionally, in 138 of these patients, HOX11 expression and SIL-TAL rearrangement were also assessed. These alterations were mutually exclusive, and their frequency was 23% (n = 35), 7% (n = 10), and 12% (n = 17), respectively. HOX11L2/t(5;14) positivity was more frequent in acute lymphoblastic leukemia (ALL) with cortical T immunophenotype and in children aged between 6 and 9 years. In contrast with previously reported data, patients positive and negative for HOX11L2/t(5;14) were comparable with regard to clinical outcome as well as to the response to a 7-day prephase treatment or to residual disease at completion of induction therapy. The 3-year event-free survival (EFS) rate (+/-SE percentage) for patients positive and negative for HOX11L2/t(5;14) was 75.5% (+/- 8.1%) and 68.3% (+/-5.0%), respectively; the hazard ratio was 0.84 (95% confidence interval, 0.40-1.80). Patients with HOX11-high expression and those with SIL-TAL fusion had low levels of residual disease at the end of induction and a favorable prognosis: the 3-year EFS rate was 83.3% (+/- 8.5%) and 75.3% (+/-12.6%), respectively. The results obtained in HOX11L2/t(5;14) patients in this study do not confirm the unfavorable prognosis reported in previous studies."xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2003-05-1495"xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2003-05-1495"xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.uniprot.org/core/author | "Cave H."xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.uniprot.org/core/author | "Cave H."xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.uniprot.org/core/author | "Hagemeijer A."xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.uniprot.org/core/author | "Hagemeijer A."xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.uniprot.org/core/author | "Uyttebroeck A."xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.uniprot.org/core/author | "Uyttebroeck A."xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.uniprot.org/core/author | "Robert A."xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.uniprot.org/core/author | "Robert A."xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.uniprot.org/core/author | "Speleman F."xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.uniprot.org/core/author | "Speleman F."xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.uniprot.org/core/author | "Lessard M."xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.uniprot.org/core/author | "Lessard M."xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.uniprot.org/core/author | "Lutz P."xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.uniprot.org/core/author | "Lutz P."xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.uniprot.org/core/author | "Bastard C."xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.uniprot.org/core/author | "Bastard C."xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.uniprot.org/core/author | "Poppe B."xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.uniprot.org/core/author | "Poppe B."xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.uniprot.org/core/author | "Dastugue N."xsd:string |
| http://purl.uniprot.org/citations/14504110 | http://purl.uniprot.org/core/author | "Dastugue N."xsd:string |