| http://purl.uniprot.org/citations/14504198 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14504198 | http://www.w3.org/2000/01/rdf-schema#comment | "Genetic polymorphism in HPC2/ELAC2 was recently associated with risk of sporadic prostate cancer. To determine the contribution of two HPC2/ELAC2 missense variants (Ser217Leu and Ala541Thr) to the risk of developing prostate cancer, we conducted a population-based case-control study of middle-aged men (40-64 years). Cases (n=591) were ascertained from the Seattle-Puget Sound Surveillance, Epidemiology, and End Results Cancer Registry and Controls (n=538) from the same general population were identified through random-digit dialing. Subjects were residents of King County, Washington, and were frequency matched on age. Cases (32%) had a slightly higher frequency of the Leu217 variant compared with controls (29%), but there were no differences in the frequency of the Thr541 allele (4%). When considering joint genotypes, white men homozygous for the Leu217 variant on an Ala541/Ala541 background had an increased risk of prostate cancer [odds ratio (OR)=1.84; 95% confidence interval (CI), 1.11-3.06]. Different risk profiles were also observed when cases were stratified by disease aggressiveness. Men with at least one Leu217 allele had an elevated risk (OR=1.34; 95% CI, 1.02-1.76) of less aggressive prostate cancer (localized stage and Gleason score < or = 7), with a stronger association among men with two Leu217 alleles (OR=1.73; 95% CI, 1.08-2.77). The Ala541Thr polymorphism was not associated with risk, and neither variant was associated with more aggressive prostate cancer phenotypes. We estimate that the Ser217Leu genotype may account for approximately 14% of less aggressive prostate cancer cases and 9% of all sporadic cases in the general United States population of white men xsd:string |
| http://purl.uniprot.org/citations/14504198 | http://purl.uniprot.org/core/author | "Feng Z."xsd:string |
| http://purl.uniprot.org/citations/14504198 | http://purl.uniprot.org/core/author | "Ostrander E.A."xsd:string |
| http://purl.uniprot.org/citations/14504198 | http://purl.uniprot.org/core/author | "Iwasaki L."xsd:string |
| http://purl.uniprot.org/citations/14504198 | http://purl.uniprot.org/core/author | "Shu J."xsd:string |
| http://purl.uniprot.org/citations/14504198 | http://purl.uniprot.org/core/author | "Stanford J.L."xsd:string |
| http://purl.uniprot.org/citations/14504198 | http://purl.uniprot.org/core/author | "Noonan E.A."xsd:string |
| http://purl.uniprot.org/citations/14504198 | http://purl.uniprot.org/core/author | "Sabacan L.P."xsd:string |
| http://purl.uniprot.org/citations/14504198 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14504198 | http://purl.uniprot.org/core/name | "Cancer Epidemiol Biomarkers Prev"xsd:string |
| http://purl.uniprot.org/citations/14504198 | http://purl.uniprot.org/core/pages | "876-881"xsd:string |
| http://purl.uniprot.org/citations/14504198 | http://purl.uniprot.org/core/title | "Association of HPC2/ELAC2 polymorphisms with risk of prostate cancer in a population-based study."xsd:string |
| http://purl.uniprot.org/citations/14504198 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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