| http://purl.uniprot.org/citations/14505570 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14505570 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14505570 | http://www.w3.org/2000/01/rdf-schema#comment | "HIV release requires TSG101, a cellular factor that sorts proteins into vesicles that bud into multivesicular bodies (MVB). To test whether other proteins involved in MVB biogenesis (the class E proteins) also participate in HIV release, we identified 22 candidate human class E proteins. These proteins were connected into a coherent network by 43 different protein-protein interactions, with AIP1 playing a key role in linking complexes that act early (TSG101/ESCRT-I) and late (CHMP4/ESCRT-III) in the pathway. AIP1 also binds the HIV-1 p6(Gag) and EIAV p9(Gag) proteins, indicating that it can function directly in virus budding. Human class E proteins were found in HIV-1 particles, and dominant-negative mutants of late-acting human class E proteins arrested HIV-1 budding through plasmal and endosomal membranes. These studies define a protein network required for human MVB biogenesis and indicate that the entire network participates in the release of HIV and probably many other viruses."xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00714-1"xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00714-1"xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.uniprot.org/core/author | "Morita E."xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.uniprot.org/core/author | "Morita E."xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.uniprot.org/core/author | "Scott A."xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.uniprot.org/core/author | "Scott A."xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.uniprot.org/core/author | "Ward D.M."xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.uniprot.org/core/author | "Ward D.M."xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.uniprot.org/core/author | "Davis T."xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.uniprot.org/core/author | "Davis T."xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.uniprot.org/core/author | "Kaplan J."xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.uniprot.org/core/author | "Kaplan J."xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.uniprot.org/core/author | "Mueller B."xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.uniprot.org/core/author | "Mueller B."xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.uniprot.org/core/author | "Morham S.G."xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.uniprot.org/core/author | "Morham S.G."xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.uniprot.org/core/author | "Sundquist W.I."xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.uniprot.org/core/author | "Sundquist W.I."xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.uniprot.org/core/author | "Wang H.E."xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.uniprot.org/core/author | "Wang H.E."xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.uniprot.org/core/author | "von Schwedler U.K."xsd:string |
| http://purl.uniprot.org/citations/14505570 | http://purl.uniprot.org/core/author | "von Schwedler U.K."xsd:string |