| http://purl.uniprot.org/citations/14506644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14506644 | http://www.w3.org/2000/01/rdf-schema#comment | "Balanced translocations are rare in myelodysplasia (MDS) and acute myeloid leukemia (AML) with multilineage dysplasia; however, the t(3;5)(q25;q35) and insertion variant occur in a subset of patients. To evaluate the possible genes involved in this translocation, we studied 6 cases with a t(3;5) by fluorescence in situ hybridization with probes directed against the nucleophosmin (NPM), EVI1, and Ribophorin genes, as well as a newly developed myeloid leukemia factor 1 (MLF1) BAC clone. The histologic spectrum of the cases was variable, ranging from refractory cytopenia with multilineage dysplasia to AML with multilineage dysplasia in the World Health Organization classification. An NPM/MLF1 fusion was identified in 5 of 6 cases, whereas the EVI1 and Ribophorin genes were not involved in any of the cases. The NPM/MLF1-positive cases were predominantly young adult males (median age, 33 years) who responded well to hematopoietic stem cell transplantation. These findings suggest that an NPM/MLF1 fusion is the primary molecular abnormality in t(3;5) MDS and AML with multilineage dysplasia, and also that cases with NPM/MLF1 may be clinically distinct from other MDS-associated disease."xsd:string |
| http://purl.uniprot.org/citations/14506644 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0046-8177(03)00251-x"xsd:string |
| http://purl.uniprot.org/citations/14506644 | http://purl.uniprot.org/core/author | "Slovak M.L."xsd:string |
| http://purl.uniprot.org/citations/14506644 | http://purl.uniprot.org/core/author | "Bedell V."xsd:string |
| http://purl.uniprot.org/citations/14506644 | http://purl.uniprot.org/core/author | "Arber D.A."xsd:string |
| http://purl.uniprot.org/citations/14506644 | http://purl.uniprot.org/core/author | "Chang K.L."xsd:string |
| http://purl.uniprot.org/citations/14506644 | http://purl.uniprot.org/core/author | "Lyda M.H."xsd:string |
| http://purl.uniprot.org/citations/14506644 | http://purl.uniprot.org/core/author | "Spielberger R."xsd:string |
| http://purl.uniprot.org/citations/14506644 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14506644 | http://purl.uniprot.org/core/name | "Hum Pathol"xsd:string |
| http://purl.uniprot.org/citations/14506644 | http://purl.uniprot.org/core/pages | "809-813"xsd:string |
| http://purl.uniprot.org/citations/14506644 | http://purl.uniprot.org/core/title | "Detection of NPM/MLF1 fusion in t(3;5)-positive acute myeloid leukemia and myelodysplasia."xsd:string |
| http://purl.uniprot.org/citations/14506644 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/14506644 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14506644 |
| http://purl.uniprot.org/citations/14506644 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14506644 |
| http://purl.uniprot.org/uniprot/#_A0A140VJQ2-mappedCitation-14506644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14506644 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4U8-mappedCitation-14506644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14506644 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z491-mappedCitation-14506644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14506644 |
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| http://purl.uniprot.org/uniprot/#_A0A0S2Z4G7-mappedCitation-14506644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14506644 |
| http://purl.uniprot.org/uniprot/#_A0A140VKD2-mappedCitation-14506644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14506644 |
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