| http://purl.uniprot.org/citations/14507782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14507782 | http://www.w3.org/2000/01/rdf-schema#comment | "Epidermal Growth Factor-receptor (Egfr) signaling is evolutionarily conserved and controls a variety of different cellular processes. In Drosophila these include proliferation, patterning, cell-fate determination, migration and survival. Here we provide evidence for a new role of Egfr signaling in controlling ommatidial rotation during planar cell polarity (PCP) establishment in the Drosophila eye. Although the signaling pathways involved in PCP establishment and photoreceptor cell-type specification are beginning to be unraveled, very little is known about the associated 90 degrees rotation process. One of the few rotation-specific mutations known is roulette (rlt) in which ommatidia rotate to a random degree, often more than 90 degrees. Here we show that rlt is a rotation-specific allele of the inhibitory Egfr ligand Argos and that modulation of Egfr activity shows defects in ommatidial rotation. Our data indicate that, beside the Raf/MAPK cascade, the Ras effector Canoe/AF6 acts downstream of Egfr/Ras and provides a link from Egfr to cytoskeletal elements in this developmentally regulated cell motility process. We provide further evidence for an involvement of cadherins and non-muscle myosin II as downstream components controlling rotation. In particular, the involvement of the cadherin Flamingo, a PCP gene, downstream of Egfr signaling provides the first link between PCP establishment and the Egfr pathway."xsd:string |
| http://purl.uniprot.org/citations/14507782 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.00759"xsd:string |
| http://purl.uniprot.org/citations/14507782 | http://purl.uniprot.org/core/author | "Mlodzik M."xsd:string |
| http://purl.uniprot.org/citations/14507782 | http://purl.uniprot.org/core/author | "Gaengel K."xsd:string |
| http://purl.uniprot.org/citations/14507782 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14507782 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/14507782 | http://purl.uniprot.org/core/pages | "5413-5423"xsd:string |
| http://purl.uniprot.org/citations/14507782 | http://purl.uniprot.org/core/title | "Egfr signaling regulates ommatidial rotation and cell motility in the Drosophila eye via MAPK/Pnt signaling and the Ras effector Canoe/AF6."xsd:string |
| http://purl.uniprot.org/citations/14507782 | http://purl.uniprot.org/core/volume | "130"xsd:string |
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| http://purl.uniprot.org/citations/14507782 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14507782 |
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| http://purl.uniprot.org/uniprot/Q00805#attribution-9EDA0879D3A0E86F7390A5E03F3C2500 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14507782 |
| http://purl.uniprot.org/uniprot/P51023#attribution-9EDA0879D3A0E86F7390A5E03F3C2500 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14507782 |
| http://purl.uniprot.org/uniprot/P08646#attribution-9EDA0879D3A0E86F7390A5E03F3C2500 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14507782 |
| http://purl.uniprot.org/uniprot/Q01083#attribution-9EDA0879D3A0E86F7390A5E03F3C2500 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14507782 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KER2-mappedCitation-14507782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14507782 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KF82-mappedCitation-14507782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14507782 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6X2-mappedCitation-14507782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14507782 |