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| http://purl.uniprot.org/citations/14510693 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent advances have been made in understanding the basis of T-cell signaling with the identification of hematopoeitic-specific adaptor proteins, or molecular scaffolds that facilitate protein complex formation and the integration of signals from the surface of T cells. Their potential relevance as targets in the modulation of transplantation relates to their immune-cell-specific expression and their ability to integrate signals needed for T-cell/APC conjugate formation, cytokine production and the clonal expansion of T cells. While LAT, GADS and SLP-76 are needed for TcR-induced cytokine production, the adaptors ADAP, VAV and SKAP-55 play specialized roles in the regulation of integrin adhesion and conjugation. Given the importance of these functions to the reactivity of T cells to allodeterminants of tissue grafts (GvH), and in the recognition and destruction of leukemic cells (GvL), these adaptors represent a new generation of potential targets in the modulation of transplantation."xsd:string |
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| http://purl.uniprot.org/citations/14510693 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/14510693 | http://purl.uniprot.org/core/author | "Rudd C.E."xsd:string |
| http://purl.uniprot.org/citations/14510693 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14510693 | http://purl.uniprot.org/core/name | "Am J Transplant"xsd:string |
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| http://purl.uniprot.org/citations/14510693 | http://purl.uniprot.org/core/title | "Hematopoietic adaptors in T-cell signaling: potential applications to transplantation."xsd:string |
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