| http://purl.uniprot.org/citations/14511668 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14511668 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14511668 | http://www.w3.org/2000/01/rdf-schema#comment | "A new metalloproteinase-disintegrin, named Jerdonitin, was purified from Trimeresurus jerdonii venom with a molecular weight of 36 kDa on SDS-PAGE. It dose-dependently inhibited ADP-induced human platelet aggregation with IC(50) of 120nM. cDNA cloning and sequencing revealed that Jerdonitin belonged to the class II of snake venom metalloproteinases (SVMPs) (P-II class). Different from other P-II class SVMPs, metalloproteinase and disintegrin domains of its natural protein were not separated, confirmed by internal peptide sequencing. Compared to other P-II class SVMPs, Jerdonitin has two additional cysteines (Cys219 and Cys238) located in the spacer domain and disintegrin domain, respectively. They probably form a disulfide bond and therefore the metalloproteinase and disintegrin domains cannot be separated by posttranslationally processing. In summary, comparison of the amino acid sequences of Jerdonitin with those of other P-II class SVMPs by sequence alignment and phylogenetic analysis, in conjunction with natural protein structure data, suggested that it was a new type of P-II class SVMPs."xsd:string |
| http://purl.uniprot.org/citations/14511668 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2003.09.009"xsd:string |
| http://purl.uniprot.org/citations/14511668 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2003.09.009"xsd:string |
| http://purl.uniprot.org/citations/14511668 | http://purl.uniprot.org/core/author | "Jin Y."xsd:string |
| http://purl.uniprot.org/citations/14511668 | http://purl.uniprot.org/core/author | "Jin Y."xsd:string |
| http://purl.uniprot.org/citations/14511668 | http://purl.uniprot.org/core/author | "Lu Q.-M."xsd:string |
| http://purl.uniprot.org/citations/14511668 | http://purl.uniprot.org/core/author | "Lu Q.-M."xsd:string |
| http://purl.uniprot.org/citations/14511668 | http://purl.uniprot.org/core/author | "Wang W.-Y."xsd:string |
| http://purl.uniprot.org/citations/14511668 | http://purl.uniprot.org/core/author | "Wang W.-Y."xsd:string |
| http://purl.uniprot.org/citations/14511668 | http://purl.uniprot.org/core/author | "Xiong Y.-L."xsd:string |
| http://purl.uniprot.org/citations/14511668 | http://purl.uniprot.org/core/author | "Xiong Y.-L."xsd:string |
| http://purl.uniprot.org/citations/14511668 | http://purl.uniprot.org/core/author | "Chen R.-Q."xsd:string |
| http://purl.uniprot.org/citations/14511668 | http://purl.uniprot.org/core/author | "Chen R.-Q."xsd:string |
| http://purl.uniprot.org/citations/14511668 | http://purl.uniprot.org/core/author | "Wu J.-B."xsd:string |
| http://purl.uniprot.org/citations/14511668 | http://purl.uniprot.org/core/author | "Wu J.-B."xsd:string |
| http://purl.uniprot.org/citations/14511668 | http://purl.uniprot.org/core/author | "Zhou X.-D."xsd:string |
| http://purl.uniprot.org/citations/14511668 | http://purl.uniprot.org/core/author | "Zhou X.-D."xsd:string |
| http://purl.uniprot.org/citations/14511668 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14511668 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14511668 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/14511668 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/14511668 | http://purl.uniprot.org/core/pages | "182-187"xsd:string |
| http://purl.uniprot.org/citations/14511668 | http://purl.uniprot.org/core/pages | "182-187"xsd:string |