| http://purl.uniprot.org/citations/14512091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14512091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14512091 | http://www.w3.org/2000/01/rdf-schema#comment | "Hainantoxin-III and hainantoxin-IV, isolated from the venom of the Chinese bird spider Seleconosmia hainana, are neurotoxic peptides composed of 33-35 residues with three disulfide bonds. Using whole-cell patch-clamp technique, we investigated their action on ionic channels of adult rat dorsal root ganglion neurons. It was found that the two toxins did not affect Ca2+ channels (both high voltage activated and low voltage activated types) nor tetrodotoxin-resistant voltage-gated Na+ channels (VGSCs). However, hainantoxin-III and hainantoxin-IV strongly depressed the amplitude of tetrodotoxin-sensitive Na+ currents with IC50 values of 1.1 and 44.6 nM, respectively. Both hainantoxin-III (1 nM) and hainantoxin-IV (50 nM) caused a hyperpolarizing shift of about 10 mV in the voltage midpoint of steady-state Na+ channel inactivation, but they showed difference in the reprime kinetics of VGSCs: hainantoxin-III significantly decreased the recovery rate from inactivation at a prepulse potential of -80 mV while hainantoxin-IV did not do. It is interesting to note that similar to huwentoxin-IV, the two hainantoxins did not affect the activation and inactivation kinetics of Na+ currents and at a concentration of 1 microM they completely inhibited the slowing inactivation currents induced by BMK-I (toxin I from the scorpion Buthus martensi Karsch), a scorpion alpha-like toxin. The results indicate that hainantoxin-III and hainantoxin-IV are novel spider toxins and affect the mammal neural Na+ channels through a mechanism quite different from other spider toxins targeting the neural receptor site 3, such as delta-aractoxins and mu-agatoxins."xsd:string |
| http://purl.uniprot.org/citations/14512091 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-2999(03)02190-3"xsd:string |
| http://purl.uniprot.org/citations/14512091 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-2999(03)02190-3"xsd:string |
| http://purl.uniprot.org/citations/14512091 | http://purl.uniprot.org/core/author | "Liang S."xsd:string |
| http://purl.uniprot.org/citations/14512091 | http://purl.uniprot.org/core/author | "Liang S."xsd:string |
| http://purl.uniprot.org/citations/14512091 | http://purl.uniprot.org/core/author | "Xiao Y."xsd:string |
| http://purl.uniprot.org/citations/14512091 | http://purl.uniprot.org/core/author | "Xiao Y."xsd:string |
| http://purl.uniprot.org/citations/14512091 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14512091 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14512091 | http://purl.uniprot.org/core/name | "Eur. J. Pharmacol."xsd:string |
| http://purl.uniprot.org/citations/14512091 | http://purl.uniprot.org/core/name | "Eur. J. Pharmacol."xsd:string |
| http://purl.uniprot.org/citations/14512091 | http://purl.uniprot.org/core/pages | "1-7"xsd:string |
| http://purl.uniprot.org/citations/14512091 | http://purl.uniprot.org/core/pages | "1-7"xsd:string |
| http://purl.uniprot.org/citations/14512091 | http://purl.uniprot.org/core/title | "Inhibition of neuronal tetrodotoxin-sensitive Na+ channels by two spider toxins: hainantoxin-III and hainantoxin-IV."xsd:string |
| http://purl.uniprot.org/citations/14512091 | http://purl.uniprot.org/core/title | "Inhibition of neuronal tetrodotoxin-sensitive Na+ channels by two spider toxins: hainantoxin-III and hainantoxin-IV."xsd:string |
| http://purl.uniprot.org/citations/14512091 | http://purl.uniprot.org/core/volume | "477"xsd:string |
| http://purl.uniprot.org/citations/14512091 | http://purl.uniprot.org/core/volume | "477"xsd:string |
| http://purl.uniprot.org/citations/14512091 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14512091 |
| http://purl.uniprot.org/citations/14512091 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14512091 |
| http://purl.uniprot.org/citations/14512091 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14512091 |
| http://purl.uniprot.org/citations/14512091 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14512091 |
| http://purl.uniprot.org/uniprot/D2Y1Z7 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/14512091 |
| http://purl.uniprot.org/uniprot/D2Y1Z8 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/14512091 |