| http://purl.uniprot.org/citations/14512161 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14512161 | http://www.w3.org/2000/01/rdf-schema#comment | "Central nervous system (CNS) damage can occur during Trypanosoma cruzi infection, especially in immunosuppressed patients. The enhanced susceptibility of C3H/He mice to CD8-mediated acute meningoencephalitis is associated with higher up-regulation of vascular cell adhesion molecule-1 (VCAM-1) on CNS vascular endothelia than in the less susceptible C57BL/6. Further, in vitro adhesion of activated peripheral blood cells to CNS blood vessels was abrogated by anti-VLA-4 antibodies that also inhibited cell migration into the CNS of T. cruzi-infected mice. Lastly, the reactivation of meningoencephalitis in immunosuppressed chronically infected mice was associated with VCAM-1 up-regulation. Therefore, we hypothesize that VLA-4/VCAM-1 pathway plays a pivotal role in the establishment of T. cruzi-elicited encephalitis."xsd:string |
| http://purl.uniprot.org/citations/14512161 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0165-5728(03)00254-6"xsd:string |
| http://purl.uniprot.org/citations/14512161 | http://purl.uniprot.org/core/author | "Roffe E."xsd:string |
| http://purl.uniprot.org/citations/14512161 | http://purl.uniprot.org/core/author | "Silva A.A."xsd:string |
| http://purl.uniprot.org/citations/14512161 | http://purl.uniprot.org/core/author | "Lannes-Vieira J."xsd:string |
| http://purl.uniprot.org/citations/14512161 | http://purl.uniprot.org/core/author | "Marino A.P."xsd:string |
| http://purl.uniprot.org/citations/14512161 | http://purl.uniprot.org/core/author | "dos Santos P.V."xsd:string |
| http://purl.uniprot.org/citations/14512161 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14512161 | http://purl.uniprot.org/core/name | "J Neuroimmunol"xsd:string |
| http://purl.uniprot.org/citations/14512161 | http://purl.uniprot.org/core/pages | "17-30"xsd:string |
| http://purl.uniprot.org/citations/14512161 | http://purl.uniprot.org/core/title | "Essential role of VLA-4/VCAM-1 pathway in the establishment of CD8+ T-cell-mediated Trypanosoma cruzi-elicited meningoencephalitis."xsd:string |
| http://purl.uniprot.org/citations/14512161 | http://purl.uniprot.org/core/volume | "142"xsd:string |
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