| http://purl.uniprot.org/citations/14514657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14514657 | http://www.w3.org/2000/01/rdf-schema#comment | "Susceptibility to gamma-ray induction of thymic lymphomas in mouse strains is controlled by low-penetrance genetic variant alleles. Our previous genome-wide scan of a mouse backcross between BALB/c and MSM strains suggested the existence of a BALB/c resistance locus near D5Mit5 on chromosome 5. To confirm this resistance, we produced congenic mice carrying a 28.4 cM region between D5Mit4 and D5Mit315 from the MSM parental strain on the BALB/c background. Lymphomas were induced in their progeny by gamma-ray irradiation or administration of N-methyl-N-nitrosourea (MNU), an alkylating agent. The incidence of radiogenic lymphomas was 87.5% in mice of the M/M genotype at D5Mit7, significantly higher than the 46% incidence in mice of the C/M genotype, indicating highly significant linkage between the locus and the resistance (P = 0.000054). In contrast, the frequencies of MNU-induced thymic lymphomas were similar between the two genotypes (P = 0.35 in chi2 test). These results confirm the presence of a resistance allele for gamma-ray induction of thymic lymphomas near the D5Mit7 locus and strongly suggest that this locus modifies carcinogenic risk from exposure to radiation but not to alkylating agents."xsd:string |
| http://purl.uniprot.org/citations/14514657 | http://purl.org/dc/terms/identifier | "doi:10.1093/carcin/bgg177"xsd:string |
| http://purl.uniprot.org/citations/14514657 | http://purl.uniprot.org/core/author | "Tamura Y."xsd:string |
| http://purl.uniprot.org/citations/14514657 | http://purl.uniprot.org/core/author | "Niwa O."xsd:string |
| http://purl.uniprot.org/citations/14514657 | http://purl.uniprot.org/core/author | "Wakana S."xsd:string |
| http://purl.uniprot.org/citations/14514657 | http://purl.uniprot.org/core/author | "Kominami R."xsd:string |
| http://purl.uniprot.org/citations/14514657 | http://purl.uniprot.org/core/author | "Kodama Y."xsd:string |
| http://purl.uniprot.org/citations/14514657 | http://purl.uniprot.org/core/author | "Yoshikai Y."xsd:string |
| http://purl.uniprot.org/citations/14514657 | http://purl.uniprot.org/core/author | "Takagi R."xsd:string |
| http://purl.uniprot.org/citations/14514657 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14514657 | http://purl.uniprot.org/core/name | "Carcinogenesis"xsd:string |
| http://purl.uniprot.org/citations/14514657 | http://purl.uniprot.org/core/pages | "143-148"xsd:string |
| http://purl.uniprot.org/citations/14514657 | http://purl.uniprot.org/core/title | "The D5Mit7 locus on mouse chromosome 5 provides resistance to gamma-ray-induced but not N-methyl-N-nitrosourea-induced thymic lymphomas."xsd:string |
| http://purl.uniprot.org/citations/14514657 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/14514657 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14514657 |
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