| http://purl.uniprot.org/citations/14515194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14515194 | http://www.w3.org/2000/01/rdf-schema#comment | "Plasminogen activator inhibitor-1 (PAI-1) is suggested to be involved in the pathophysiology of early thrombosis and late restenosis after percutaneous transluminal angioplasty (PTA). The role of the PAI-1 promoter genotype in this context is indeterminate. We investigated the association of the (4G/5G) polymorphism at nucleotide position (-675) in the PAI-1 gene promoter, PAI-1 plasma levels, and postangioplasty outcome after femoropopliteal PTA. We studied 251 consecutive patients who underwent femoro-popliteal PTA. In a subgroup of 86 patients PAI-1 plasma levels at baseline, 8, 24 and 48 hours postintervention were measured and correlated to the genotype. Patients were followed for early thrombosis and the late restenosis (> or =50%) within 12 months. Multivariate Cox proportional hazards analysis was performed to assess the association between the PAI-1 genotype and PTA failure. Results show that the PAI-1 genotype was neither associated with PAI-1 plasma levels (p=0.40) nor the change of PAI-1 from baseline to 8 (p=0.39), 24 (p=0.86) and 48 hours (p=0.89). Three out of 35 homozygous (4G/4G) patients (9%) had early thrombotic reocclusions, compared to two out of 153 heterozygous (4G/5G) patients (1%) and none of the 63 homozygous (5G/5G) patients (p=0.007). Restenosis after median 5 months (interquartile range 3 to 9) was found in 117 patients (42%), without significant association between the PAI-1 genotype and late postangioplasty failure (Log Rank p=0.95). We can conclude that carriers of the 4G allele exhibited a higher frequency of early thrombotic reocclusions after percutaneous angioplasty. However, the PAI-1 gene promoter polymorphism (4G/5G) was not associated with PAI-1 plasma levels or late postangioplasty restenosis."xsd:string |
| http://purl.uniprot.org/citations/14515194 | http://purl.org/dc/terms/identifier | "doi:10.1160/th03-03-0159"xsd:string |
| http://purl.uniprot.org/citations/14515194 | http://purl.uniprot.org/core/author | "Exner M."xsd:string |
| http://purl.uniprot.org/citations/14515194 | http://purl.uniprot.org/core/author | "Wagner O."xsd:string |
| http://purl.uniprot.org/citations/14515194 | http://purl.uniprot.org/core/author | "Mannhalter C."xsd:string |
| http://purl.uniprot.org/citations/14515194 | http://purl.uniprot.org/core/author | "Schillinger M."xsd:string |
| http://purl.uniprot.org/citations/14515194 | http://purl.uniprot.org/core/author | "Minar E."xsd:string |
| http://purl.uniprot.org/citations/14515194 | http://purl.uniprot.org/core/author | "Mlekusch W."xsd:string |
| http://purl.uniprot.org/citations/14515194 | http://purl.uniprot.org/core/author | "Sabeti S."xsd:string |
| http://purl.uniprot.org/citations/14515194 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14515194 | http://purl.uniprot.org/core/name | "Thromb Haemost"xsd:string |
| http://purl.uniprot.org/citations/14515194 | http://purl.uniprot.org/core/pages | "717-723"xsd:string |
| http://purl.uniprot.org/citations/14515194 | http://purl.uniprot.org/core/title | "Plasminogen activator inhibitor-1 and outcome after femoropopliteal angioplasty: analysis of genotype and plasma levels."xsd:string |
| http://purl.uniprot.org/citations/14515194 | http://purl.uniprot.org/core/volume | "90"xsd:string |
| http://purl.uniprot.org/citations/14515194 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14515194 |
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