| http://purl.uniprot.org/citations/14515274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14515274 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitogen-activated protein kinase (MAPK) cascades play essential roles in the transduction of extracellular signals to cytoplasmic and nuclear effectors. The MAPK kinase kinase MEKK2 is essential for activation of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase 5 (ERK5). These pathways are important for expression of specific cytokine genes in mast cells following cross-linking of the high-affinity IgE receptor (FcepsilonRI). A consequence of ERK5 activation is activation of the transcriptional factor myocyte enhancing factor-2C (MEF2C), leading to increased c-Jun expression. We have investigated the role of MEF2C activation in mast cells and demonstrated that it requires sequential activation of the signaling cascade of MEKK2-MEK5-ERK5. Following phosphorylation of MEF2C, activated MEF2C regulates transcription of c-Jun but not TNF-alpha. Inhibition of ERK5, MEK5 activation or activation of MEKK2-deficient mast cells was associated with inhibition of MEF2C phosphorylation and a decrease in c-Jun expression. Thus, these data define an activation module, MEKK2-MEK5-ERK5-MEF2C in the transcriptional activation of c-Jun in mast cells following FcepsilonRI cross-linking. These results demonstrate the novel and important, MEKK2-dependent role of MEF2C in induction of c-Jun expression in mast cells activated through FcepsilonRI, a pathway distinct from that involving MEKK2-MEK5-ERK5 in the regulation of mast cell cytokine production."xsd:string |
| http://purl.uniprot.org/citations/14515274 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200324127"xsd:string |
| http://purl.uniprot.org/citations/14515274 | http://purl.uniprot.org/core/author | "Li G."xsd:string |
| http://purl.uniprot.org/citations/14515274 | http://purl.uniprot.org/core/author | "Fan R."xsd:string |
| http://purl.uniprot.org/citations/14515274 | http://purl.uniprot.org/core/author | "Sun W."xsd:string |
| http://purl.uniprot.org/citations/14515274 | http://purl.uniprot.org/core/author | "Wei X."xsd:string |
| http://purl.uniprot.org/citations/14515274 | http://purl.uniprot.org/core/author | "Lucas J."xsd:string |
| http://purl.uniprot.org/citations/14515274 | http://purl.uniprot.org/core/author | "Hahn J."xsd:string |
| http://purl.uniprot.org/citations/14515274 | http://purl.uniprot.org/core/author | "Webb S."xsd:string |
| http://purl.uniprot.org/citations/14515274 | http://purl.uniprot.org/core/author | "Gelfand E.W."xsd:string |
| http://purl.uniprot.org/citations/14515274 | http://purl.uniprot.org/core/author | "Johnson G.L."xsd:string |
| http://purl.uniprot.org/citations/14515274 | http://purl.uniprot.org/core/author | "Joetham A."xsd:string |
| http://purl.uniprot.org/citations/14515274 | http://purl.uniprot.org/core/author | "Dakhama A."xsd:string |
| http://purl.uniprot.org/citations/14515274 | http://purl.uniprot.org/core/author | "Garrington T."xsd:string |
| http://purl.uniprot.org/citations/14515274 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14515274 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/14515274 | http://purl.uniprot.org/core/pages | "2903-2909"xsd:string |
| http://purl.uniprot.org/citations/14515274 | http://purl.uniprot.org/core/title | "MEF2C regulates c-Jun but not TNF-alpha gene expression in stimulated mast cells."xsd:string |
| http://purl.uniprot.org/citations/14515274 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/14515274 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14515274 |
| http://purl.uniprot.org/citations/14515274 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14515274 |
| http://purl.uniprot.org/uniprot/Q8CFN5#attribution-9E559349F2CA210BB9B303F5948A0543 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14515274 |
| http://purl.uniprot.org/uniprot/Q9Y2U5#attribution-9E559349F2CA210BB9B303F5948A0543 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14515274 |
| http://purl.uniprot.org/uniprot/Q9WVS8#attribution-9E559349F2CA210BB9B303F5948A0543 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14515274 |