| http://purl.uniprot.org/citations/14517243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14517243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14517243 | http://www.w3.org/2000/01/rdf-schema#comment | "Retinal phosducin is known to sequester transducin Gbetagamma, thereby modulating transducin activity. Phosducin is a member of a family of phosducin-like proteins (PhLP) found in eukaryotes. Phylogeny of 33 phosducin-like proteins from metazoa, plants and lower eukaryotes identified three distinct groups named phosducin-I-III. We discovered three phlp genes in Dictyostelium, each encoding a phosducin-like protein of a different group. Disruption of the phlp1 gene strongly impaired G-protein signalling, apparently due to mislocalization of Gbetagamma in phlp1-null cells. GFP-Gbeta and GFP-Ggamma are membrane associated in wild-type cells, but cytosolic in phlp1-null cells. Phlp2 disruption is lethal due to a synchronous collapse of the cells after 16-17 cell divisions. Phlp3 disruptants show no abnormal phenotype. These results establish a role for phosducin-like proteins in facilitating folding, localization or function of proteins, in addition to modulating G-protein signalling."xsd:string |
| http://purl.uniprot.org/citations/14517243 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg508"xsd:string |
| http://purl.uniprot.org/citations/14517243 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg508"xsd:string |
| http://purl.uniprot.org/citations/14517243 | http://purl.uniprot.org/core/author | "Blaauw M."xsd:string |
| http://purl.uniprot.org/citations/14517243 | http://purl.uniprot.org/core/author | "Blaauw M."xsd:string |
| http://purl.uniprot.org/citations/14517243 | http://purl.uniprot.org/core/author | "Knol J.C."xsd:string |
| http://purl.uniprot.org/citations/14517243 | http://purl.uniprot.org/core/author | "Knol J.C."xsd:string |
| http://purl.uniprot.org/citations/14517243 | http://purl.uniprot.org/core/author | "Kortholt A."xsd:string |
| http://purl.uniprot.org/citations/14517243 | http://purl.uniprot.org/core/author | "Kortholt A."xsd:string |
| http://purl.uniprot.org/citations/14517243 | http://purl.uniprot.org/core/author | "Postma M."xsd:string |
| http://purl.uniprot.org/citations/14517243 | http://purl.uniprot.org/core/author | "Postma M."xsd:string |
| http://purl.uniprot.org/citations/14517243 | http://purl.uniprot.org/core/author | "Roelofs J."xsd:string |
| http://purl.uniprot.org/citations/14517243 | http://purl.uniprot.org/core/author | "Roelofs J."xsd:string |
| http://purl.uniprot.org/citations/14517243 | http://purl.uniprot.org/core/author | "Ruchira X."xsd:string |
| http://purl.uniprot.org/citations/14517243 | http://purl.uniprot.org/core/author | "Ruchira X."xsd:string |
| http://purl.uniprot.org/citations/14517243 | http://purl.uniprot.org/core/author | "Visser A.J.W.G."xsd:string |
| http://purl.uniprot.org/citations/14517243 | http://purl.uniprot.org/core/author | "Visser A.J.W.G."xsd:string |
| http://purl.uniprot.org/citations/14517243 | http://purl.uniprot.org/core/author | "van Haastert P.J.M."xsd:string |
| http://purl.uniprot.org/citations/14517243 | http://purl.uniprot.org/core/author | "van Haastert P.J.M."xsd:string |
| http://purl.uniprot.org/citations/14517243 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14517243 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14517243 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/14517243 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |