| http://purl.uniprot.org/citations/14517244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14517244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14517244 | http://www.w3.org/2000/01/rdf-schema#comment | "Signaling by fibroblast growth factors (FGFs) and their receptors has been previously implicated in control of cell proliferation, differentiation and migration. Here we report a novel role for signaling by the EGL-15 FGFR of Caenorhabditis elegans in controlling protein degradation in differentiated muscle. Activation of EGL-15, by means of a reduction of function mutation (clr-1) affecting an inhibitory phosphatase, triggers protein degradation in adult muscle cells using a pre-existing proteolytic system. This activation is not suppressed by mutation in either of the known genes encoding FGF ligands (egl-17 or let-756) but is well suppressed when both are mutated, indicating that either ligand is sufficient and at least one is necessary for FGFR activation. Activity of the Ras pathway through mitogen-activated protein kinase (MAPK) is required to trigger protein degradation. This is the first report that degradation of intracellular protein can be triggered by a growth factor receptor using an identified signal transduction pathway. The data raise the possibility that FGF-triggered proteolysis may be relevant to muscle remodeling or dedifferentiation."xsd:string |
| http://purl.uniprot.org/citations/14517244 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg472"xsd:string |
| http://purl.uniprot.org/citations/14517244 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg472"xsd:string |
| http://purl.uniprot.org/citations/14517244 | http://purl.uniprot.org/core/author | "Jacobson L.A."xsd:string |
| http://purl.uniprot.org/citations/14517244 | http://purl.uniprot.org/core/author | "Jacobson L.A."xsd:string |
| http://purl.uniprot.org/citations/14517244 | http://purl.uniprot.org/core/author | "Szewczyk N.J."xsd:string |
| http://purl.uniprot.org/citations/14517244 | http://purl.uniprot.org/core/author | "Szewczyk N.J."xsd:string |
| http://purl.uniprot.org/citations/14517244 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14517244 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14517244 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/14517244 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/14517244 | http://purl.uniprot.org/core/pages | "5058-5067"xsd:string |
| http://purl.uniprot.org/citations/14517244 | http://purl.uniprot.org/core/pages | "5058-5067"xsd:string |
| http://purl.uniprot.org/citations/14517244 | http://purl.uniprot.org/core/title | "Activated EGL-15 FGF receptor promotes protein degradation in muscles of Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/14517244 | http://purl.uniprot.org/core/title | "Activated EGL-15 FGF receptor promotes protein degradation in muscles of Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/14517244 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/14517244 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/14517244 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14517244 |
| http://purl.uniprot.org/citations/14517244 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14517244 |
| http://purl.uniprot.org/citations/14517244 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14517244 |
| http://purl.uniprot.org/citations/14517244 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14517244 |
| http://purl.uniprot.org/uniprot/Q10656 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/14517244 |
| http://purl.uniprot.org/uniprot/H2KZM6 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/14517244 |