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| http://purl.uniprot.org/citations/14517293 | http://www.w3.org/2000/01/rdf-schema#comment | "Myostatin, a transforming growth factor beta (TGF-beta) family member, is a potent negative regulator of skeletal muscle growth. In this study we characterized the myostatin signal transduction pathway and examined its effect on bone morphogenetic protein (BMP)-induced adipogenesis. While both BMP7 and BMP2 activated transcription from the BMP-responsive I-BRE-Lux reporter and induced adipogenic differentiation, myostatin inhibited BMP7-but not BMP2-mediated responses. To dissect the molecular mechanism of this antagonism, we characterized the myostatin signal transduction pathway. We showed that myostatin binds the type II Ser/Thr kinase receptor. ActRIIB, and then partners with a type I receptor, either activin receptor-like kinase 4 (ALK4 or ActRIB) or ALK5 (TbetaRI), to induce phosphorylation of Smad2/Smad3 and activate a TGF-beta-like signaling pathway. We demonstrated that myostatin prevents BMP7 but not BMP2 binding to its receptors and that BMP7-induced heteromeric receptor complex formation is blocked by competition for the common type II receptor, ActRIIB. Thus, our results reveal a strikingly specific antagonism of BMP7-mediated processes by myostatin and suggest that myostatin is an important regulator of adipogenesis."xsd:string |
| http://purl.uniprot.org/citations/14517293 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.23.20.7230-7242.2003"xsd:string |
| http://purl.uniprot.org/citations/14517293 | http://purl.uniprot.org/core/author | "Rebbapragada A."xsd:string |
| http://purl.uniprot.org/citations/14517293 | http://purl.uniprot.org/core/author | "Attisano L."xsd:string |
| http://purl.uniprot.org/citations/14517293 | http://purl.uniprot.org/core/author | "Wrana J.L."xsd:string |
| http://purl.uniprot.org/citations/14517293 | http://purl.uniprot.org/core/author | "Celeste A.J."xsd:string |
| http://purl.uniprot.org/citations/14517293 | http://purl.uniprot.org/core/author | "Benchabane H."xsd:string |
| http://purl.uniprot.org/citations/14517293 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14517293 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/14517293 | http://purl.uniprot.org/core/pages | "7230-7242"xsd:string |
| http://purl.uniprot.org/citations/14517293 | http://purl.uniprot.org/core/title | "Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis."xsd:string |
| http://purl.uniprot.org/citations/14517293 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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