| http://purl.uniprot.org/citations/14517297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14517297 | http://www.w3.org/2000/01/rdf-schema#comment | "Our studies address questions pertaining to the regulation of D cyclin-cdk4 activity, and the following results were obtained. Conditions that increased the abundance of the D cyclins also increased the abundance of enzymatically active D cyclin-cdk4 complexes in mouse embryo fibroblasts (MEFs) lacking both p27(Kip1) and p21(Cip1) (p27/p21(-/-)). Such conditions included ectopic expression of cyclin D1 and inhibition of D cyclin degradation by the proteasome inhibitor MG132. However, as determined by treatment of wild-type MEFs with MG132, maximal accumulation of D cyclin-cdk4 complexes required p27(Kip1) and p21(Cip1) and coincided with the formation of inactive D cyclin-cdk4-p27(Kip1) or -p21(Cip1) complexes. p27(Kip1) or p21(Cip1) also increased the abundance of D cyclin-cdk4 complexes and reduced amounts of cdk4 activity when ectopically expressed in p27/p21(-/-) MEFs. Lastly, increases in the stability of the D cyclins accounted for their greater abundance in wild-type MEFs than in p27/p21(-/-) MEFs. We conclude that (i) D cyclin-cdk4 complexes are formed and become active in the absence of p27(Kip1) and p21(Cip1) and (ii) p27(Kip1) and p21(Cip1) maximize the accumulation but inhibit the activity of D cyclin-cdk4 complexes. We suggest that D cyclin-cdk4 complexes are more stable when bound to p27(Kip1) or p21(Cip1) and that formation of ternary complexes also stabilizes the D cyclins."xsd:string |
| http://purl.uniprot.org/citations/14517297 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.23.20.7285-7290.2003"xsd:string |
| http://purl.uniprot.org/citations/14517297 | http://purl.uniprot.org/core/author | "Mohapatra S."xsd:string |
| http://purl.uniprot.org/citations/14517297 | http://purl.uniprot.org/core/author | "Bagui T.K."xsd:string |
| http://purl.uniprot.org/citations/14517297 | http://purl.uniprot.org/core/author | "Pledger W.J."xsd:string |
| http://purl.uniprot.org/citations/14517297 | http://purl.uniprot.org/core/author | "Haura E."xsd:string |
| http://purl.uniprot.org/citations/14517297 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14517297 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/14517297 | http://purl.uniprot.org/core/pages | "7285-7290"xsd:string |
| http://purl.uniprot.org/citations/14517297 | http://purl.uniprot.org/core/title | "P27Kip1 and p21Cip1 are not required for the formation of active D cyclin-cdk4 complexes."xsd:string |
| http://purl.uniprot.org/citations/14517297 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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