| http://purl.uniprot.org/citations/14519458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14519458 | http://www.w3.org/2000/01/rdf-schema#comment | "Over the past decade or so it has become widely recognised that the brain is a significant steroidogenic organ. Many publications have highlighted the ability of the brain to synthesise and interconvert a large number of steroid products including cholesterol, progesterone and testosterone. In this study, in vitro experiments were performed to determine if 21-hydroxylation of steroids is undertaken by rat brain astrocytes in culture. This is a common reaction that occurs in the adrenal gland and other organs in mammals, catalysing the conversion of pregn-4-ene-3,20-dione (progesterone) to 21-hydroxypregn-4-ene-3,20-dione (deoxycorticosterone). Previous reports have indicated that 21-hydroxylation occurs within the rat brain, however, the precise identity of the cells expressing 21-hydroxylase has not yet been determined. Several metabolites, such as 5alpha-pregnan-3alpha-ol-20-one (tetrahydroprogesterone) and 3alpha,21-dihydroxy-5-pregnan-20-one (tetrahydrodeoxycorticosterone) were of particular interest because of their modulatory role in neuronal function, such as their agonist activity at gamma-aminobutyric acid (GABA(A)) receptors. Evidence was obtained for the expression of peripheral 21-hydroxylase enzyme (P450c21) in cultured rat brain astrocytes by a combination of mass spectroscopy and molecular biology techniques. This is a significant finding as expression of 21-hydroxylase within astrocytes may be indicative of a wider role for these cells in modulating neuronal behaviour."xsd:string |
| http://purl.uniprot.org/citations/14519458 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.brainresbull.2003.07.003"xsd:string |
| http://purl.uniprot.org/citations/14519458 | http://purl.uniprot.org/core/author | "Watson T.G."xsd:string |
| http://purl.uniprot.org/citations/14519458 | http://purl.uniprot.org/core/author | "Lovelace M."xsd:string |
| http://purl.uniprot.org/citations/14519458 | http://purl.uniprot.org/core/author | "Stephenson G.L."xsd:string |
| http://purl.uniprot.org/citations/14519458 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14519458 | http://purl.uniprot.org/core/name | "Brain Res Bull"xsd:string |
| http://purl.uniprot.org/citations/14519458 | http://purl.uniprot.org/core/pages | "609-615"xsd:string |
| http://purl.uniprot.org/citations/14519458 | http://purl.uniprot.org/core/title | "Steroid 21-hydroxylase expression in cultured rat astrocytes."xsd:string |
| http://purl.uniprot.org/citations/14519458 | http://purl.uniprot.org/core/volume | "61"xsd:string |
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