| http://purl.uniprot.org/citations/14519665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14519665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14519665 | http://www.w3.org/2000/01/rdf-schema#comment | "Proteinase-activated receptor-2 belongs to a new subfamily of G-protein-coupled receptors. Its precise role during inflammation and the underlying mechanisms is still unclear. Our study establishes that PAR-2 plays a direct proinflammatory role during cutaneous inflammation in mice and humans in vivo. In a model of experimentally induced allergic (ACD) and toxic (ICD) contact dermatitis (CD) we show that ear swelling responses, plasma extravasation, and leucocyte adherence were significantly attenuated in PAR-2 null mutant (PAR-2-/-) mice compared with wild-type (PAR-2+/+) mice, especially at early stages. The proinflammatory effects by PAR-2 activation were significantly diminished using nitric oxide-synthase inhibitors, while NF-kappaB and neuropeptides appear to play a minor role in these mechanisms. PAR-2-mediated up-regulation of E-selectin and cell adhesion molecule ICAM-1; enhanced plasma extravasation was observed in humans and mice and of interleukin-6 in mice in vivo. Thus, PAR-2 may be a beneficial therapeutic target for the treatment of inflammatory skin diseases."xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.02-1112com"xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.02-1112com"xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.uniprot.org/core/author | "Harms E."xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.uniprot.org/core/author | "Harms E."xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.uniprot.org/core/author | "Bunnett N.W."xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.uniprot.org/core/author | "Bunnett N.W."xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.uniprot.org/core/author | "Vestweber D."xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.uniprot.org/core/author | "Vestweber D."xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.uniprot.org/core/author | "Nawroth R."xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.uniprot.org/core/author | "Nawroth R."xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.uniprot.org/core/author | "Andrade-Gordon P."xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.uniprot.org/core/author | "Andrade-Gordon P."xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.uniprot.org/core/author | "Derian C.K."xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.uniprot.org/core/author | "Derian C.K."xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.uniprot.org/core/author | "Metze D."xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.uniprot.org/core/author | "Metze D."xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.uniprot.org/core/author | "Schmelz M."xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.uniprot.org/core/author | "Schmelz M."xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.uniprot.org/core/author | "Buddenkotte J."xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.uniprot.org/core/author | "Buddenkotte J."xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.uniprot.org/core/author | "Steinhoff M."xsd:string |
| http://purl.uniprot.org/citations/14519665 | http://purl.uniprot.org/core/author | "Steinhoff M."xsd:string |