| http://purl.uniprot.org/citations/14519765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14519765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14519765 | http://www.w3.org/2000/01/rdf-schema#comment | "Lipopolysaccharide (LPS) is an agonist for Toll-like receptor (TLR) 4 and expresses many genes including NF-kappaB- and interferon regulatory factor (IRF)-3/IFN-inducible genes in macrophages and dendritic cells (DCs). TICAM-1/TRIF was identified as an adapter that facilitates activation of IRF-3 followed by expression of interferon (IFN)-beta genes in TLR3 signaling, but TICAM-1 does not directly bind TLR4. Although MyD88 and Mal/TIRAP adapters functions downstream of TLR4, DC maturation and IFN-beta induction are independent of MyD88 and Mal/TIRAP. In this investigation, we report the identification of a novel adapter, TICAM-2, that physically bridges TLR4 and TICAM-1 and functionally transmits LPS-TLR4 signaling to TICAM-1, which in turn activates IRF-3. In its structural features, TICAM-2 resembled Mal/TIRAP, an adapter that links TLR2/4 and MyD88. However, TICAM-2 per se exhibited minimal ability to activate NF-kappaB and the IFN-beta promoter. Hence, in LPS signaling TLR4 recruits two types of adapters, TIRAP and TICAM-2, to its cytoplasmic domain that are indirectly connected to two effective adapters, MyD88 and TICAM-1, respectively. We conclude that for LPS-TLR4-mediated activation of IFN-beta, the adapter complex of TICAM-2 and TICAM-1 plays a crucial role. This results in the construction of MyD88-dependent and -independent pathways separately downstream of the two distinct adapters."xsd:string |
| http://purl.uniprot.org/citations/14519765 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m305820200"xsd:string |
| http://purl.uniprot.org/citations/14519765 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m305820200"xsd:string |
| http://purl.uniprot.org/citations/14519765 | http://purl.uniprot.org/core/author | "Matsumoto M."xsd:string |
| http://purl.uniprot.org/citations/14519765 | http://purl.uniprot.org/core/author | "Matsumoto M."xsd:string |
| http://purl.uniprot.org/citations/14519765 | http://purl.uniprot.org/core/author | "Fujita T."xsd:string |
| http://purl.uniprot.org/citations/14519765 | http://purl.uniprot.org/core/author | "Fujita T."xsd:string |
| http://purl.uniprot.org/citations/14519765 | http://purl.uniprot.org/core/author | "Seya T."xsd:string |
| http://purl.uniprot.org/citations/14519765 | http://purl.uniprot.org/core/author | "Seya T."xsd:string |
| http://purl.uniprot.org/citations/14519765 | http://purl.uniprot.org/core/author | "Oshiumi H."xsd:string |
| http://purl.uniprot.org/citations/14519765 | http://purl.uniprot.org/core/author | "Oshiumi H."xsd:string |
| http://purl.uniprot.org/citations/14519765 | http://purl.uniprot.org/core/author | "Sasai M."xsd:string |
| http://purl.uniprot.org/citations/14519765 | http://purl.uniprot.org/core/author | "Sasai M."xsd:string |
| http://purl.uniprot.org/citations/14519765 | http://purl.uniprot.org/core/author | "Shida K."xsd:string |
| http://purl.uniprot.org/citations/14519765 | http://purl.uniprot.org/core/author | "Shida K."xsd:string |
| http://purl.uniprot.org/citations/14519765 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14519765 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14519765 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14519765 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14519765 | http://purl.uniprot.org/core/pages | "49751-49762"xsd:string |
| http://purl.uniprot.org/citations/14519765 | http://purl.uniprot.org/core/pages | "49751-49762"xsd:string |
| http://purl.uniprot.org/citations/14519765 | http://purl.uniprot.org/core/title | "TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta."xsd:string |
| http://purl.uniprot.org/citations/14519765 | http://purl.uniprot.org/core/title | "TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta."xsd:string |