| http://purl.uniprot.org/citations/14519844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14519844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14519844 | http://www.w3.org/2000/01/rdf-schema#comment | "The release of enveloped viruses from infected cells often requires a virally encoded activity, termed a late-budding domain (L domain), encoded by essential PTAP, PPXY, or YPDL sequence motifs. PTAP-type L domains recruit one of three endosomal sorting complexes required for transport (ESCRT-I). However, subsequent events in viral budding are poorly defined, and neither YPDL nor PPXY-type L domains require ESCRT-I. Here, we show that ESCRT-I and other class E vacuolar protein sorting (VPS) factors are linked by a complex series of protein-protein interactions. In particular, interactions between ESCRT-I and ESCRT-III are bridged by AIP-1/ALIX, a mammalian orthologue of the yeast class E VPS factor, Bro1. Expression of certain ESCRT-III components as fusion proteins induces a late budding defect that afflicts all three L-domain types, suggesting that ESCRT-III integrity is required in a general manner. Notably, the prototype YPDL-type L domain encoded by equine infectious anemia virus (EIAV) acts by recruiting AIP-1/ALIX and expression of a truncated form of AIP-1/ALIX or small interfering RNA-induced AIP-1/ALIX depletion specifically inhibits EIAV YPDL-type L-domain function. Overall, these findings indicate that L domains subvert a subset of class E VPS factors to mediate viral budding, some of which are required for each of the L-domain types, whereas others apparently act as adaptors to physically link specific L-domain types to the class E VPS machinery."xsd:string |
| http://purl.uniprot.org/citations/14519844 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2133846100"xsd:string |
| http://purl.uniprot.org/citations/14519844 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2133846100"xsd:string |
| http://purl.uniprot.org/citations/14519844 | http://purl.uniprot.org/core/author | "Bieniasz P.D."xsd:string |
| http://purl.uniprot.org/citations/14519844 | http://purl.uniprot.org/core/author | "Bieniasz P.D."xsd:string |
| http://purl.uniprot.org/citations/14519844 | http://purl.uniprot.org/core/author | "Martin-Serrano J."xsd:string |
| http://purl.uniprot.org/citations/14519844 | http://purl.uniprot.org/core/author | "Martin-Serrano J."xsd:string |
| http://purl.uniprot.org/citations/14519844 | http://purl.uniprot.org/core/author | "Perez-Caballero D."xsd:string |
| http://purl.uniprot.org/citations/14519844 | http://purl.uniprot.org/core/author | "Perez-Caballero D."xsd:string |
| http://purl.uniprot.org/citations/14519844 | http://purl.uniprot.org/core/author | "Yarovoy A."xsd:string |
| http://purl.uniprot.org/citations/14519844 | http://purl.uniprot.org/core/author | "Yarovoy A."xsd:string |
| http://purl.uniprot.org/citations/14519844 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14519844 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14519844 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/14519844 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/14519844 | http://purl.uniprot.org/core/pages | "12414-12419"xsd:string |
| http://purl.uniprot.org/citations/14519844 | http://purl.uniprot.org/core/pages | "12414-12419"xsd:string |
| http://purl.uniprot.org/citations/14519844 | http://purl.uniprot.org/core/title | "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins."xsd:string |
| http://purl.uniprot.org/citations/14519844 | http://purl.uniprot.org/core/title | "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins."xsd:string |
| http://purl.uniprot.org/citations/14519844 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/14519844 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/14519844 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14519844 |
| http://purl.uniprot.org/citations/14519844 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14519844 |