| http://purl.uniprot.org/citations/14522093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14522093 | http://www.w3.org/2000/01/rdf-schema#comment | "Associations of human leukocyte antigen DR2 (HLA-DR2) and HLA-B7 with presumed ocular histoplasmosis syndrome (POHS) in the United States has been previously described. However, these associations were determined by means of low-resolution, complement-dependent cytotoxicity assays for HLA-A, HLA-B, and HLA-DR molecules. To determine whether POHS is associated with other HLA alleles within the HLA-A, HLA-B, HLA-DR, and HLA-DQ loci, we performed a case control study of 34 patients diagnosed with macular choroidal neovascular membrane secondary to POHS and 45 healthy control individuals. Peripheral blood-derived DNA from the study patients was typed for HLA genes by means of sequence-specific primers that gave low-medium allele resolution. Significant associations were observed between HLA-B7 (X2 = 14.30, pc = 0.004, relative risk = 8.23), HLA-DR15 (X2 = 29.08, pc = 0.000001, relative risk = 27.50), and HLA-DQ6 (X2 = 23.09, pc = 0.00001, relative risk = 27.43) and POHS. Because there are strong linkage disequilibria between HLA-DR15 (a subtype of HLA-DR2) and HLA-B7 as well as HLA-DQ6, the significantly higher association of HLA-DR15 and HLA-DQ6 with POHS as compared to HLA-B7 suggests that the former alleles mediate susceptibility to the disease. In conclusion, there is a significant association between the HLA-DR15/HLA-DQ6 haplotype and development of choroidal neovascular lesions in POHS."xsd:string |
| http://purl.uniprot.org/citations/14522093 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0198-8859(03)00175-7"xsd:string |
| http://purl.uniprot.org/citations/14522093 | http://purl.uniprot.org/core/author | "Jaramillo A."xsd:string |
| http://purl.uniprot.org/citations/14522093 | http://purl.uniprot.org/core/author | "Mohanakumar T."xsd:string |
| http://purl.uniprot.org/citations/14522093 | http://purl.uniprot.org/core/author | "Kaplan H.J."xsd:string |
| http://purl.uniprot.org/citations/14522093 | http://purl.uniprot.org/core/author | "Duffy B.F."xsd:string |
| http://purl.uniprot.org/citations/14522093 | http://purl.uniprot.org/core/author | "Dabil H."xsd:string |
| http://purl.uniprot.org/citations/14522093 | http://purl.uniprot.org/core/author | "Phelan D.L."xsd:string |
| http://purl.uniprot.org/citations/14522093 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14522093 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |
| http://purl.uniprot.org/citations/14522093 | http://purl.uniprot.org/core/pages | "960-964"xsd:string |
| http://purl.uniprot.org/citations/14522093 | http://purl.uniprot.org/core/title | "Association of the HLA-DR15/HLA-DQ6 haplotype with development of choroidal neovascular lesions in presumed ocular histoplasmosis syndrome."xsd:string |
| http://purl.uniprot.org/citations/14522093 | http://purl.uniprot.org/core/volume | "64"xsd:string |
| http://purl.uniprot.org/citations/14522093 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14522093 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-14522093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14522093 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-14522093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14522093 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-14522093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14522093 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-14522093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14522093 |
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| http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-14522093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14522093 |