| http://purl.uniprot.org/citations/14522994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14522994 | http://www.w3.org/2000/01/rdf-schema#comment | "The protein tyrosine phosphatase SHP-2 is an important regulator of the Janus kinase-2 (Jak2)/signal transducer and activator of transcription (Stat) pathway downstream of the cytokine/prolactin receptor family. We report that SHP-2 dephosphorylates tyrosine (Tyr-1007) of Jak2 kinase, a critical recruitment site for the ubiquitin ligase-associated inhibitory protein suppressor of cytokine signaling-1 (SOCS-1), thereby contributing to Jak2 stability. Inactivation of SHP-2 function by blocking receptor/SHP-2 association or by using a catalytically inactive mutant of SHP-2 led to a marked increase in Jak2 ubiquitination/degradation, Jak2 phosphorylation on Tyr-1007, and Jak2/SOCS-1 association. Furthermore, functional studies indicate that modulating the interaction of Jak2/SOCS-1 by SHP-2 is essential for prolactin/Stat5-mediated signaling. Together our results provide a novel function for SHP-2 as a positive regulator of cytokine receptor signaling by regulating ubiquitination/degradation pathways."xsd:string |
| http://purl.uniprot.org/citations/14522994 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m306758200"xsd:string |
| http://purl.uniprot.org/citations/14522994 | http://purl.uniprot.org/core/author | "Ali S."xsd:string |
| http://purl.uniprot.org/citations/14522994 | http://purl.uniprot.org/core/author | "Nouhi Z."xsd:string |
| http://purl.uniprot.org/citations/14522994 | http://purl.uniprot.org/core/author | "Ali S.'"xsd:string |
| http://purl.uniprot.org/citations/14522994 | http://purl.uniprot.org/core/author | "Chughtai N."xsd:string |
| http://purl.uniprot.org/citations/14522994 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14522994 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/14522994 | http://purl.uniprot.org/core/pages | "52021-52031"xsd:string |
| http://purl.uniprot.org/citations/14522994 | http://purl.uniprot.org/core/title | "SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor."xsd:string |
| http://purl.uniprot.org/citations/14522994 | http://purl.uniprot.org/core/volume | "278"xsd:string |
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