| http://purl.uniprot.org/citations/14526028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14526028 | http://www.w3.org/2000/01/rdf-schema#comment | "Escherichia coli responses to four inhibitors that interfere with translation were monitored at the transcriptional level. A DNA microarray method provided a comprehensive view of changes in mRNA levels after exposure to these agents. Real-time reverse transcriptase PCRanalysis served to verify observations made with microarrays, and a chromosomal grpE::lux operon fusion was employed to specifically monitor the heat shock response. 4-Azaleucine, a competitive inhibitor of leucyl-tRNA synthetase, surprisingly triggered the heat shock response. Administration of mupirocin, an inhibitor of isoleucyl-tRNA synthetase activity, resulted in changes reminiscent of the stringent response. Treatment with kasugamycin and puromycin (targeting ribosomal subunit association as well as its peptidyl-transferase activity) caused accumulation of mRNAs from ribosomal protein operons. Abundant biosynthetic transcripts were often significantly diminished after treatment with any of these agents. Exposure of a relA strain to mupirocin resulted in accumulation of ribosomal protein operon transcripts. However, the relA strain's response to the other inhibitors was quite similar to that of the wild-type strain."xsd:string |
| http://purl.uniprot.org/citations/14526028 | http://purl.org/dc/terms/identifier | "doi:10.1128/jb.185.20.6158-6170.2003"xsd:string |
| http://purl.uniprot.org/citations/14526028 | http://purl.uniprot.org/core/author | "Soll D."xsd:string |
| http://purl.uniprot.org/citations/14526028 | http://purl.uniprot.org/core/author | "Templeton L.J."xsd:string |
| http://purl.uniprot.org/citations/14526028 | http://purl.uniprot.org/core/author | "Sabina J."xsd:string |
| http://purl.uniprot.org/citations/14526028 | http://purl.uniprot.org/core/author | "LaRossa R.A."xsd:string |
| http://purl.uniprot.org/citations/14526028 | http://purl.uniprot.org/core/author | "Smulski D.R."xsd:string |
| http://purl.uniprot.org/citations/14526028 | http://purl.uniprot.org/core/author | "Dover N."xsd:string |
| http://purl.uniprot.org/citations/14526028 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14526028 | http://purl.uniprot.org/core/name | "J Bacteriol"xsd:string |
| http://purl.uniprot.org/citations/14526028 | http://purl.uniprot.org/core/pages | "6158-6170"xsd:string |
| http://purl.uniprot.org/citations/14526028 | http://purl.uniprot.org/core/title | "Interfering with different steps of protein synthesis explored by transcriptional profiling of Escherichia coli K-12."xsd:string |
| http://purl.uniprot.org/citations/14526028 | http://purl.uniprot.org/core/volume | "185"xsd:string |
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