| http://purl.uniprot.org/citations/14527430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14527430 | http://www.w3.org/2000/01/rdf-schema#comment | "I(Ks) voltage-gated K(+) channels contain four pore-forming KCNQ1 subunits and MinK accessory subunits in a number that has been controversial. Here, I(Ks) channels assembled naturally by monomer subunits are compared to those with linked subunits that force defined stoichiometries. Two strategies that exploit charybdotoxin (CTX)-sensitive subunit variants are applied. First, CTX on rate, off rate, and equilibrium affinity are found to be the same for channels of monomers and those with a fixed 2:4 MinK:KCNQ1 valence. Second, 3H-CTX and an antibody are used to directly quantify channels and MinK subunits, respectively, showing 1.97 +/-0.07 MinK per I(Ks) channel. Additional MinK subunits do not enter channels of monomeric subunits or those with fixed 2:4 valence. We conclude that two MinK subunits are necessary, sufficient, and the norm in I(Ks) channels. This stoichiometry is expected for other K(+) channels that contain MinK or MinK-related peptides (MiRPs)."xsd:string |
| http://purl.uniprot.org/citations/14527430 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(03)00570-1"xsd:string |
| http://purl.uniprot.org/citations/14527430 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/14527430 | http://purl.uniprot.org/core/author | "Xu S."xsd:string |
| http://purl.uniprot.org/citations/14527430 | http://purl.uniprot.org/core/author | "Rajan S."xsd:string |
| http://purl.uniprot.org/citations/14527430 | http://purl.uniprot.org/core/author | "Goldstein S.A."xsd:string |
| http://purl.uniprot.org/citations/14527430 | http://purl.uniprot.org/core/author | "Kim L.A."xsd:string |
| http://purl.uniprot.org/citations/14527430 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14527430 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/14527430 | http://purl.uniprot.org/core/pages | "15-23"xsd:string |
| http://purl.uniprot.org/citations/14527430 | http://purl.uniprot.org/core/title | "Charybdotoxin binding in the I(Ks) pore demonstrates two MinK subunits in each channel complex."xsd:string |
| http://purl.uniprot.org/citations/14527430 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/14527430 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14527430 |
| http://purl.uniprot.org/citations/14527430 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14527430 |
| http://purl.uniprot.org/uniprot/#_P15382-mappedCitation-14527430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14527430 |
| http://purl.uniprot.org/uniprot/#_C7S316-mappedCitation-14527430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14527430 |
| http://purl.uniprot.org/uniprot/#_A7LFK2-mappedCitation-14527430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14527430 |
| http://purl.uniprot.org/uniprot/#_A7LFK4-mappedCitation-14527430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14527430 |
| http://purl.uniprot.org/uniprot/#_B4E2L9-mappedCitation-14527430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14527430 |
| http://purl.uniprot.org/uniprot/#_Q5DI96-mappedCitation-14527430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14527430 |
| http://purl.uniprot.org/uniprot/#_Q6FHJ6-mappedCitation-14527430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14527430 |
| http://purl.uniprot.org/uniprot/C7S316 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14527430 |
| http://purl.uniprot.org/uniprot/P15382 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14527430 |
| http://purl.uniprot.org/uniprot/Q5DI96 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14527430 |