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http://purl.uniprot.org/citations/14527733http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/14527733http://www.w3.org/2000/01/rdf-schema#comment"

Background

Predisposing genetic factors in psoriasis include associations with human leukocyte antigen (HLA). Accumulative evidence has shown that certain HLA at class I locus, especially HLA-Cw6, are associated closely with psoriasis.

Objective

To evaluate the association of HLA class I alleles with susceptibility to psoriasis in the southeastern Chinese Han population.

Methods

We performed genotype for HLA-A, -B and -C loci in 166 patients with psoriasis vulgaris by means of polymerase chain reaction with sequence-specific primers technique. The distribution of HLA allelic frequencies was further analyzed according to age of onset, i.e. under 35-y and beyond 35-y groups. These data were compared with the healthy controls of 204 unrelated Hans.

Results

The frequencies of HLA-A*26 (24.7% vs. 13.1%, OR=2.36, Pc<0.01), -B*13 (27.2% vs. 14.8%, OR=2.34, Pc<0.01), -B*27 (12.2% vs. 4.0%, OR=3.49, Pc<0.01) and -Cw*0602 (17.9% vs. 5.3%, OR=4.20, Pc<0.001) were significantly increased in psoriasis patients, whereas HLA-Cw*0304 frequency (4.9% vs. 13.4%, OR=0.32, Pc<0.01) was highly decreased, when compared to the controls. HLA-A*26-B*27-Cw*0602 was identified as a high-risk haplotype of HLA class I in developing psoriasis in the test. HLA-Cw*0602 was found to be strongly associated with the early-onset psoriasis (age of onset <35 y).

Conclusion

This study demonstrated the positive associations of HLA class I markers with psoriasis vulgaris, of which HLA-Cw*0602 was the strongest susceptibility determinant for development of early-onset psoriasis, in the southeastern Chinese Han population."xsd:string
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http://purl.uniprot.org/citations/14527733http://purl.uniprot.org/core/author"Gao M."xsd:string
http://purl.uniprot.org/citations/14527733http://purl.uniprot.org/core/author"Yang S."xsd:string
http://purl.uniprot.org/citations/14527733http://purl.uniprot.org/core/author"Zhang A.P."xsd:string
http://purl.uniprot.org/citations/14527733http://purl.uniprot.org/core/author"Zhang X.J."xsd:string
http://purl.uniprot.org/citations/14527733http://purl.uniprot.org/core/author"Cui Y."xsd:string
http://purl.uniprot.org/citations/14527733http://purl.uniprot.org/core/author"Wang H.Y."xsd:string
http://purl.uniprot.org/citations/14527733http://purl.uniprot.org/core/author"Chen J.J."xsd:string
http://purl.uniprot.org/citations/14527733http://purl.uniprot.org/core/author"Wei S.C."xsd:string
http://purl.uniprot.org/citations/14527733http://purl.uniprot.org/core/author"He P.P."xsd:string
http://purl.uniprot.org/citations/14527733http://purl.uniprot.org/core/author"Song Y.X."xsd:string
http://purl.uniprot.org/citations/14527733http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/14527733http://purl.uniprot.org/core/name"J Dermatol Sci"xsd:string
http://purl.uniprot.org/citations/14527733http://purl.uniprot.org/core/pages"1-6"xsd:string
http://purl.uniprot.org/citations/14527733http://purl.uniprot.org/core/title"Association of HLA class I alleles with psoriasis vulgaris in southeastern Chinese Hans."xsd:string
http://purl.uniprot.org/citations/14527733http://purl.uniprot.org/core/volume"33"xsd:string
http://purl.uniprot.org/citations/14527733http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/14527733
http://purl.uniprot.org/citations/14527733http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/14527733
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