| http://purl.uniprot.org/citations/14530259 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14530259 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14530259 | http://www.w3.org/2000/01/rdf-schema#comment | "Mi-2 beta is the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Here we show that the amino-terminal and carboxyl-terminal regions of Mi-2 beta have distinct transcriptional activities and bind to BRG1, a component of the SWI/SNF complex, and the RET finger protein (RFP), respectively. Analysis by luciferase reporter assay revealed that the amino-terminal region of Mi-2 beta has a strong transactivating ability, whereas its carboxyl-terminal region has transcriptional repressive activity. Co-localization and association of Mi-2, RFP, and histone deacetylase 1 suggested that these proteins cooperate in transcriptional repression. Furthermore, the functional importance of the association of Mi-2 beta and RFP was confirmed by using Rfp-/-fibroblasts. On the other hand, we demonstrated that Mi-2 and BRG1 were associated with each other and that the bromodomain region of BRG1 strongly suppressed transactivation by the amino-terminal region of Mi-2 beta. The findings that Mi-2 beta interacts with both transactivating and repressing proteins and directly associates with another chromatin remodeling protein, BRG1, provide new insight into the formation of multiprotein supercomplex involved in transcriptional regulation."xsd:string |
| http://purl.uniprot.org/citations/14530259 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m309198200"xsd:string |
| http://purl.uniprot.org/citations/14530259 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m309198200"xsd:string |
| http://purl.uniprot.org/citations/14530259 | http://purl.uniprot.org/core/author | "Murakami H."xsd:string |
| http://purl.uniprot.org/citations/14530259 | http://purl.uniprot.org/core/author | "Murakami H."xsd:string |
| http://purl.uniprot.org/citations/14530259 | http://purl.uniprot.org/core/author | "Takahashi M."xsd:string |
| http://purl.uniprot.org/citations/14530259 | http://purl.uniprot.org/core/author | "Takahashi M."xsd:string |
| http://purl.uniprot.org/citations/14530259 | http://purl.uniprot.org/core/author | "Shimono Y."xsd:string |
| http://purl.uniprot.org/citations/14530259 | http://purl.uniprot.org/core/author | "Shimono Y."xsd:string |
| http://purl.uniprot.org/citations/14530259 | http://purl.uniprot.org/core/author | "Kawai K."xsd:string |
| http://purl.uniprot.org/citations/14530259 | http://purl.uniprot.org/core/author | "Kawai K."xsd:string |
| http://purl.uniprot.org/citations/14530259 | http://purl.uniprot.org/core/author | "Wade P.A."xsd:string |
| http://purl.uniprot.org/citations/14530259 | http://purl.uniprot.org/core/author | "Wade P.A."xsd:string |
| http://purl.uniprot.org/citations/14530259 | http://purl.uniprot.org/core/author | "Shimokata K."xsd:string |
| http://purl.uniprot.org/citations/14530259 | http://purl.uniprot.org/core/author | "Shimokata K."xsd:string |
| http://purl.uniprot.org/citations/14530259 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14530259 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14530259 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14530259 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14530259 | http://purl.uniprot.org/core/pages | "51638-51645"xsd:string |
| http://purl.uniprot.org/citations/14530259 | http://purl.uniprot.org/core/pages | "51638-51645"xsd:string |
| http://purl.uniprot.org/citations/14530259 | http://purl.uniprot.org/core/title | "Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities."xsd:string |
| http://purl.uniprot.org/citations/14530259 | http://purl.uniprot.org/core/title | "Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities."xsd:string |