| http://purl.uniprot.org/citations/14530267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14530267 | http://www.w3.org/2000/01/rdf-schema#comment | "Depletion of intracellular Ca2+ stores leads to the activation of Ca2+ inflow through store-operated Ca2+ channels. Although the identity of these channels is unknown, there is considerable evidence that the transient receptor potential channel 1 (TRPC1) participates in the formation of these channels. We show that TRPC1 physically interacts with the a-isoform of the inhibitor of the myogenic family (I-mfa), a known inhibitor of basic helix-loop-helix transcription factors, in vitro and in vivo. The interaction is mediated by the C-terminal cytoplasmic tail of TRPC1 and the C-terminal cysteine-rich domain of I-mfa. Using the whole cell configuration of the patch clamp technique, we show that ectopic expression of I-mfa in CHO-K1 cells reduces native store-activated Ca2+ currents, whereas knock-down of endogenous I-mfa in A431 cells by RNA interference enhances these currents. Pipette perfusion of purified recombinant I-mfa rescues the effect of I-mfa knock-down on store-operated conductance. Finally, cell dialysis with a monoclonal antibody specific to TRPC1 results in the suppression of store-activated conductance in cells lacking I-mfa, but not in I-mfa expressing cells. We propose that I-mfa functions as a molecular switch to suppress the store dependence of TRPC1."xsd:string |
| http://purl.uniprot.org/citations/14530267 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m309610200"xsd:string |
| http://purl.uniprot.org/citations/14530267 | http://purl.uniprot.org/core/author | "Koch M."xsd:string |
| http://purl.uniprot.org/citations/14530267 | http://purl.uniprot.org/core/author | "Ma R."xsd:string |
| http://purl.uniprot.org/citations/14530267 | http://purl.uniprot.org/core/author | "Tsiokas L."xsd:string |
| http://purl.uniprot.org/citations/14530267 | http://purl.uniprot.org/core/author | "Downs T."xsd:string |
| http://purl.uniprot.org/citations/14530267 | http://purl.uniprot.org/core/author | "Jacks J."xsd:string |
| http://purl.uniprot.org/citations/14530267 | http://purl.uniprot.org/core/author | "Rundle D."xsd:string |
| http://purl.uniprot.org/citations/14530267 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14530267 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/14530267 | http://purl.uniprot.org/core/pages | "52763-52772"xsd:string |
| http://purl.uniprot.org/citations/14530267 | http://purl.uniprot.org/core/title | "Inhibitor of myogenic family, a novel suppressor of store-operated currents through an interaction with TRPC1."xsd:string |
| http://purl.uniprot.org/citations/14530267 | http://purl.uniprot.org/core/volume | "278"xsd:string |
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