| http://purl.uniprot.org/citations/14530399 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14530399 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14530399 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the parkin gene are linked to autosomal-recessive juvenile parkinsonism (AR-JP). Parkin functions as a ubiquitin protein ligase in the degradation of several proteins, including the neuron-specific septin CDCrel-1. AR-JP-associated parkin mutations inhibit ubiquitination and degradation of CDCrel-1 and other parkin target proteins. Here we show that recombinant adeno-associated virus-mediated CDCrel-1 gene transfer to the substantia nigra of rats results in a rapid onset (6-10 days) of nigral and striatal CDCrel-1 expression that is followed by a progressive loss of nigral dopaminergic neurons and a decline of the striatal dopamine levels. In contrast, neurons of the globus pallidus are spared from CDCrel-1 toxicity. Furthermore, CDCrel-1 inhibits the release of dopamine from stably-transfected PC12 cells, and pharmacological inhibition of tyrosine hydroxylase and dopamine synthesis in rats prevents CDCrel-1-induced nigral neurodegeneration. These results show that CDCrel-1 overexpression exerts dopamine-dependent neurotoxicity and suggest that inhibition of dopamine secretion by CDCrel-1 may contribute to the development of AR-JP."xsd:string |
| http://purl.uniprot.org/citations/14530399 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2132992100"xsd:string |
| http://purl.uniprot.org/citations/14530399 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2132992100"xsd:string |
| http://purl.uniprot.org/citations/14530399 | http://purl.uniprot.org/core/author | "Dong Z."xsd:string |
| http://purl.uniprot.org/citations/14530399 | http://purl.uniprot.org/core/author | "Dong Z."xsd:string |
| http://purl.uniprot.org/citations/14530399 | http://purl.uniprot.org/core/author | "Vogel D."xsd:string |
| http://purl.uniprot.org/citations/14530399 | http://purl.uniprot.org/core/author | "Vogel D."xsd:string |
| http://purl.uniprot.org/citations/14530399 | http://purl.uniprot.org/core/author | "Feldon J."xsd:string |
| http://purl.uniprot.org/citations/14530399 | http://purl.uniprot.org/core/author | "Feldon J."xsd:string |
| http://purl.uniprot.org/citations/14530399 | http://purl.uniprot.org/core/author | "Bueeler H."xsd:string |
| http://purl.uniprot.org/citations/14530399 | http://purl.uniprot.org/core/author | "Bueeler H."xsd:string |
| http://purl.uniprot.org/citations/14530399 | http://purl.uniprot.org/core/author | "Ferger B."xsd:string |
| http://purl.uniprot.org/citations/14530399 | http://purl.uniprot.org/core/author | "Ferger B."xsd:string |
| http://purl.uniprot.org/citations/14530399 | http://purl.uniprot.org/core/author | "Furler S."xsd:string |
| http://purl.uniprot.org/citations/14530399 | http://purl.uniprot.org/core/author | "Furler S."xsd:string |
| http://purl.uniprot.org/citations/14530399 | http://purl.uniprot.org/core/author | "Osinde M."xsd:string |
| http://purl.uniprot.org/citations/14530399 | http://purl.uniprot.org/core/author | "Osinde M."xsd:string |
| http://purl.uniprot.org/citations/14530399 | http://purl.uniprot.org/core/author | "Paterna J.-C."xsd:string |
| http://purl.uniprot.org/citations/14530399 | http://purl.uniprot.org/core/author | "Paterna J.-C."xsd:string |
| http://purl.uniprot.org/citations/14530399 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14530399 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14530399 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/14530399 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |