| http://purl.uniprot.org/citations/14532282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14532282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14532282 | http://www.w3.org/2000/01/rdf-schema#comment | "HCF-1 is a transcriptional cofactor required for activation of herpes simplex virus immediate-early genes by VP16 as well as less clearly defined roles in cell proliferation, cytokinesis, and spliceosome formation. It is expressed as a large precursor that undergoes proteolysis to yield two subunits that remain stably associated. VP16 uses a degenerate 4-amino acid sequence, known as the HCF-binding motif, to bind to a six-bladed beta-propeller domain at the N terminus of HCF-1. Functional HCF-binding motifs are also found in LZIP and Zhangfei, two cellular bZIP transcription factors of unknown function. Here we show that the HCF-binding motif occurs in a wide spectrum of DNA-binding proteins and transcriptional cofactors. Three well characterized examples were further analyzed for their ability to use HCF-1 as a coactivator. Krox20, a zinc finger transcription factor required for Schwann cell differentiation, and E2F4, a cell cycle regulator, showed a strong requirement for functional HCF-1 to activate transcription. In contrast, activation by estrogen receptor-alpha did not display HCF dependence. In Krox20, the HCF-binding motif lies within the N-terminal activation domain and mutation of this sequence diminishes both transactivation and association with the HCF-1 beta-propeller. The activation domain in the C-terminal subunit of HCF-1 contributes to activation by Krox20, possibly through recruitment of p300. These results suggest that HCF-1 is recruited by many different classes of cellular transcription factors and is therefore likely to be required for a variety of cellular processes including cell cycle progression and development."xsd:string |
| http://purl.uniprot.org/citations/14532282 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m303470200"xsd:string |
| http://purl.uniprot.org/citations/14532282 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m303470200"xsd:string |
| http://purl.uniprot.org/citations/14532282 | http://purl.uniprot.org/core/author | "Wilson A.C."xsd:string |
| http://purl.uniprot.org/citations/14532282 | http://purl.uniprot.org/core/author | "Wilson A.C."xsd:string |
| http://purl.uniprot.org/citations/14532282 | http://purl.uniprot.org/core/author | "Luciano R.L."xsd:string |
| http://purl.uniprot.org/citations/14532282 | http://purl.uniprot.org/core/author | "Luciano R.L."xsd:string |
| http://purl.uniprot.org/citations/14532282 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14532282 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14532282 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14532282 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14532282 | http://purl.uniprot.org/core/pages | "51116-51124"xsd:string |
| http://purl.uniprot.org/citations/14532282 | http://purl.uniprot.org/core/pages | "51116-51124"xsd:string |
| http://purl.uniprot.org/citations/14532282 | http://purl.uniprot.org/core/title | "HCF-1 functions as a coactivator for the zinc finger protein Krox20."xsd:string |
| http://purl.uniprot.org/citations/14532282 | http://purl.uniprot.org/core/title | "HCF-1 functions as a coactivator for the zinc finger protein Krox20."xsd:string |
| http://purl.uniprot.org/citations/14532282 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/14532282 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/14532282 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14532282 |
| http://purl.uniprot.org/citations/14532282 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14532282 |
| http://purl.uniprot.org/citations/14532282 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14532282 |
| http://purl.uniprot.org/citations/14532282 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14532282 |
| http://purl.uniprot.org/uniprot/P51610 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/14532282 |
| http://purl.uniprot.org/uniprot/Q16254 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/14532282 |