| http://purl.uniprot.org/citations/1453482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1453482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1453482 | http://www.w3.org/2000/01/rdf-schema#comment | "Myelin/oligodendrocyte glycoprotein (MOG) is a primary target autoantigen in experimental autoimmune encephalomyelitis, a widely used animal model for autoimmune demyelinating diseases such as multiple sclerosis. We have isolated several rat MOG cDNAs and confirmed their identity by comparison with MOG N-terminal peptide sequence. As expected, MOG mRNA expression is CNS-specific and peaks during active myelination. Our studies show that full length MOG mRNA is approximately 1.6 kb and encodes a signal peptide of 27 amino acids, followed by 218 residues for mature MOG (24,962 MW). A single site for N-glycosylation is found at Asn-31. Rather than the ubiquitous AAUAAA polyadenylation signal, a series of three overlapping, rare poly A signals were identified. The N-terminal half of mature MOG shares 52% identity with bovine butyrophilin, a possible lipid receptor. This same region has 39% identity with chicken B-G antigen, a major histocompatibility complex antigen involved in B cell selection and immune repertoire development. We show that both MOG and butyrophilin, each exhibiting a single Ig-like variable region domain, meet criteria for inclusion in the immunoglobulin superfamily. Moreover, MOG appears to represent a unique member of this superfamily in that it possesses two potential transmembrane domains, in contrast to a single membrane-spanning domain or glycophospholipid anchor found in all other members of Ig superfamily members."xsd:string |
| http://purl.uniprot.org/citations/1453482 | http://purl.org/dc/terms/identifier | "doi:10.1002/jnr.490330123"xsd:string |
| http://purl.uniprot.org/citations/1453482 | http://purl.org/dc/terms/identifier | "doi:10.1002/jnr.490330123"xsd:string |
| http://purl.uniprot.org/citations/1453482 | http://purl.uniprot.org/core/author | "Amiguet P."xsd:string |
| http://purl.uniprot.org/citations/1453482 | http://purl.uniprot.org/core/author | "Amiguet P."xsd:string |
| http://purl.uniprot.org/citations/1453482 | http://purl.uniprot.org/core/author | "Gardinier M.V."xsd:string |
| http://purl.uniprot.org/citations/1453482 | http://purl.uniprot.org/core/author | "Gardinier M.V."xsd:string |
| http://purl.uniprot.org/citations/1453482 | http://purl.uniprot.org/core/author | "Linington C."xsd:string |
| http://purl.uniprot.org/citations/1453482 | http://purl.uniprot.org/core/author | "Linington C."xsd:string |
| http://purl.uniprot.org/citations/1453482 | http://purl.uniprot.org/core/author | "Matthieu J.-M."xsd:string |
| http://purl.uniprot.org/citations/1453482 | http://purl.uniprot.org/core/author | "Matthieu J.-M."xsd:string |
| http://purl.uniprot.org/citations/1453482 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1453482 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1453482 | http://purl.uniprot.org/core/name | "J. Neurosci. Res."xsd:string |
| http://purl.uniprot.org/citations/1453482 | http://purl.uniprot.org/core/name | "J. Neurosci. Res."xsd:string |
| http://purl.uniprot.org/citations/1453482 | http://purl.uniprot.org/core/pages | "177-187"xsd:string |
| http://purl.uniprot.org/citations/1453482 | http://purl.uniprot.org/core/pages | "177-187"xsd:string |
| http://purl.uniprot.org/citations/1453482 | http://purl.uniprot.org/core/title | "Myelin/oligodendrocyte glycoprotein is a unique member of the immunoglobulin superfamily."xsd:string |
| http://purl.uniprot.org/citations/1453482 | http://purl.uniprot.org/core/title | "Myelin/oligodendrocyte glycoprotein is a unique member of the immunoglobulin superfamily."xsd:string |
| http://purl.uniprot.org/citations/1453482 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/1453482 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/1453482 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1453482 |
| http://purl.uniprot.org/citations/1453482 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1453482 |