| http://purl.uniprot.org/citations/14550764 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14550764 | http://www.w3.org/2000/01/rdf-schema#comment | "Rat peripheral nerve Schwann cells have been shown to express the alpha-chemokine receptor CXCR4 as well as the corresponding ligand stromal cell-derived factor-1 (SDF-1). We have investigated gene regulatory mechanisms acting on the expression of CXCR4 in cultured rat Schwann cells and found that receptor expression at transcript- and protein levels is directly dependent on intracellular cyclic AMP. Such increased levels of CXCR4 expression were found to be efficiently reversed by the action of tumor necrosis factor-alpha (TNFalpha). We also provide evidence that the POU box transcription factor Oct-6/SCIP is involved in the control of CXCR4 transcription. Finally, we could demonstrate that CXCR4 activation by SDF-1alpha increases the number of dying Schwann cells, indicating that this receptor/ligand interaction is modulating cell survival. Our data, therefore, suggest that in the Schwann cell lineage signal transduction cascades controlled by the activation of TNF- and CXCR4 receptors are functionally coupled."xsd:string |
| http://purl.uniprot.org/citations/14550764 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1044-7431(03)00132-5"xsd:string |
| http://purl.uniprot.org/citations/14550764 | http://purl.uniprot.org/core/author | "Cornely C."xsd:string |
| http://purl.uniprot.org/citations/14550764 | http://purl.uniprot.org/core/author | "Hamacher M."xsd:string |
| http://purl.uniprot.org/citations/14550764 | http://purl.uniprot.org/core/author | "Muller H.W."xsd:string |
| http://purl.uniprot.org/citations/14550764 | http://purl.uniprot.org/core/author | "Hasse B."xsd:string |
| http://purl.uniprot.org/citations/14550764 | http://purl.uniprot.org/core/author | "Kury P."xsd:string |
| http://purl.uniprot.org/citations/14550764 | http://purl.uniprot.org/core/author | "Koller H."xsd:string |
| http://purl.uniprot.org/citations/14550764 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14550764 | http://purl.uniprot.org/core/name | "Mol Cell Neurosci"xsd:string |
| http://purl.uniprot.org/citations/14550764 | http://purl.uniprot.org/core/pages | "1-9"xsd:string |
| http://purl.uniprot.org/citations/14550764 | http://purl.uniprot.org/core/title | "Cyclic AMP and tumor necrosis factor-alpha regulate CXCR4 gene expression in Schwann cells."xsd:string |
| http://purl.uniprot.org/citations/14550764 | http://purl.uniprot.org/core/volume | "24"xsd:string |
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