| http://purl.uniprot.org/citations/14555962 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14555962 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14555962 | http://www.w3.org/2000/01/rdf-schema#comment | "Endocytosis by clathrin-coated vesicles (CCVs) is an important mechanism mediating protein internalization. Here, we show that two proteins identified through a proteomics analysis of CCVs are new components of the endocytic machinery. The proteins, named NECAP (adaptin-ear-binding coat-associated protein) 1 and 2, are paralogues that display no sequence similarity or common domains with any known protein. Both are enriched in CCV coats, and further analysis of the brain-enriched isoform, NECAP 1, shows its partial localization to clathrin-coated pits and direct binding to the globular ear domain of the alpha-adaptin subunit (alpha-ear) of the adaptor protein 2 (AP-2) complex. Intriguingly, this interaction is mediated by a new motif, WVQF, that uses a distinct alpha-ear interface relative to known alpha-ear-binding partners. Disruption of this interaction blocks clathrin-mediated endocytosis. Together, our studies identify a new family of endocytic proteins that define a unique AP-2-binding motif."xsd:string |
| http://purl.uniprot.org/citations/14555962 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.embor.embor7400004"xsd:string |
| http://purl.uniprot.org/citations/14555962 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.embor.embor7400004"xsd:string |
| http://purl.uniprot.org/citations/14555962 | http://purl.uniprot.org/core/author | "McPherson P.S."xsd:string |
| http://purl.uniprot.org/citations/14555962 | http://purl.uniprot.org/core/author | "McPherson P.S."xsd:string |
| http://purl.uniprot.org/citations/14555962 | http://purl.uniprot.org/core/author | "Girard M."xsd:string |
| http://purl.uniprot.org/citations/14555962 | http://purl.uniprot.org/core/author | "Girard M."xsd:string |
| http://purl.uniprot.org/citations/14555962 | http://purl.uniprot.org/core/author | "Ritter B."xsd:string |
| http://purl.uniprot.org/citations/14555962 | http://purl.uniprot.org/core/author | "Ritter B."xsd:string |
| http://purl.uniprot.org/citations/14555962 | http://purl.uniprot.org/core/author | "Philie J."xsd:string |
| http://purl.uniprot.org/citations/14555962 | http://purl.uniprot.org/core/author | "Philie J."xsd:string |
| http://purl.uniprot.org/citations/14555962 | http://purl.uniprot.org/core/author | "Blondeau F."xsd:string |
| http://purl.uniprot.org/citations/14555962 | http://purl.uniprot.org/core/author | "Blondeau F."xsd:string |
| http://purl.uniprot.org/citations/14555962 | http://purl.uniprot.org/core/author | "Tung E.C."xsd:string |
| http://purl.uniprot.org/citations/14555962 | http://purl.uniprot.org/core/author | "Tung E.C."xsd:string |
| http://purl.uniprot.org/citations/14555962 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14555962 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14555962 | http://purl.uniprot.org/core/name | "EMBO Rep."xsd:string |
| http://purl.uniprot.org/citations/14555962 | http://purl.uniprot.org/core/name | "EMBO Rep."xsd:string |
| http://purl.uniprot.org/citations/14555962 | http://purl.uniprot.org/core/pages | "1089-1095"xsd:string |
| http://purl.uniprot.org/citations/14555962 | http://purl.uniprot.org/core/pages | "1089-1095"xsd:string |
| http://purl.uniprot.org/citations/14555962 | http://purl.uniprot.org/core/title | "Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif."xsd:string |
| http://purl.uniprot.org/citations/14555962 | http://purl.uniprot.org/core/title | "Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif."xsd:string |