| http://purl.uniprot.org/citations/14555988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14555988 | http://www.w3.org/2000/01/rdf-schema#comment | "Smad transcription factors mediate the growth inhibitory effect of transforming growth factor-beta (TGF-beta) in many cell types. Mutational inactivation of Smads has been correlated with loss of responsiveness to TGF-beta-mediated signal transduction. In this study, we compare the contribution of individual Smads to TGF-beta-induced growth inhibition and endogenous gene expression in isogenic cellular backgrounds. Smad2, Smad3 and Smad4 expression were selectively inhibited in differentiation-competent cells by using improved antisense molecules. We found that TGF-beta mediates its inhibitory effect on HaCaT keratinocyte cell growth predominantly through Smad3. Inhibition of Smad3 expression was sufficient to interfere with TGF-beta-induced cell cycle arrest and to induce or suppress endogenous cell cycle regulators. Inhibition of Smad4 expression exhibited a partial effect, whereas inhibition of Smad2 expression had no effect. By gene expression profiling, we identified TGF-beta-dependent genes that are differentially regulated by Smad2 and Smad3 under regular growth conditions on a genome-wide scale. We show that Smad2, Smad3 and Smad4 contribute to the regulation of TGF-beta responses to varying extents, and demonstrate, in addition, that these Smads exhibit distinct roles in different cell types."xsd:string |
| http://purl.uniprot.org/citations/14555988 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1206791"xsd:string |
| http://purl.uniprot.org/citations/14555988 | http://purl.uniprot.org/core/author | "Dames S."xsd:string |
| http://purl.uniprot.org/citations/14555988 | http://purl.uniprot.org/core/author | "Kaufmann J."xsd:string |
| http://purl.uniprot.org/citations/14555988 | http://purl.uniprot.org/core/author | "Klippel A."xsd:string |
| http://purl.uniprot.org/citations/14555988 | http://purl.uniprot.org/core/author | "Kretschmer A."xsd:string |
| http://purl.uniprot.org/citations/14555988 | http://purl.uniprot.org/core/author | "Moepert K."xsd:string |
| http://purl.uniprot.org/citations/14555988 | http://purl.uniprot.org/core/author | "Sternberger M."xsd:string |
| http://purl.uniprot.org/citations/14555988 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14555988 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/14555988 | http://purl.uniprot.org/core/pages | "6748-6763"xsd:string |
| http://purl.uniprot.org/citations/14555988 | http://purl.uniprot.org/core/title | "Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4."xsd:string |
| http://purl.uniprot.org/citations/14555988 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/14555988 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14555988 |
| http://purl.uniprot.org/citations/14555988 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14555988 |
| http://purl.uniprot.org/uniprot/Q15796#attribution-3E60473ED3F046199D2A5DBFC1775E6D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14555988 |
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