| http://purl.uniprot.org/citations/14556004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14556004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14556004 | http://www.w3.org/2000/01/rdf-schema#comment | "Recognition of pathogens by Toll-like receptors (TLRs) triggers innate immune responses through signaling pathways mediated by Toll-interleukin 1 receptor (TIR) domain-containing adaptors such as MyD88, TIRAP and TRIF. MyD88 is a common adaptor that is essential for proinflammatory cytokine production, whereas TRIF mediates the MyD88-independent pathway from TLR3 and TLR4. Here we have identified a fourth TIR domain-containing adaptor, TRIF-related adaptor molecule (TRAM), and analyzed its physiological function by gene targeting. TRAM-deficient mice showed defects in cytokine production in response to the TLR4 ligand, but not to other TLR ligands. TLR4-but not TLR3-mediated MyD88-independent interferon-beta production and activation of signaling cascades were abolished in TRAM-deficient cells. Thus, TRAM provides specificity for the MyD88-independent component of TLR4 signaling."xsd:string |
| http://purl.uniprot.org/citations/14556004 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni986"xsd:string |
| http://purl.uniprot.org/citations/14556004 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni986"xsd:string |
| http://purl.uniprot.org/citations/14556004 | http://purl.uniprot.org/core/author | "Hemmi H."xsd:string |
| http://purl.uniprot.org/citations/14556004 | http://purl.uniprot.org/core/author | "Hemmi H."xsd:string |
| http://purl.uniprot.org/citations/14556004 | http://purl.uniprot.org/core/author | "Sato S."xsd:string |
| http://purl.uniprot.org/citations/14556004 | http://purl.uniprot.org/core/author | "Sato S."xsd:string |
| http://purl.uniprot.org/citations/14556004 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/14556004 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/14556004 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/14556004 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/14556004 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/14556004 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/14556004 | http://purl.uniprot.org/core/author | "Hoshino K."xsd:string |
| http://purl.uniprot.org/citations/14556004 | http://purl.uniprot.org/core/author | "Hoshino K."xsd:string |
| http://purl.uniprot.org/citations/14556004 | http://purl.uniprot.org/core/author | "Kaisho T."xsd:string |
| http://purl.uniprot.org/citations/14556004 | http://purl.uniprot.org/core/author | "Kaisho T."xsd:string |
| http://purl.uniprot.org/citations/14556004 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/14556004 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/14556004 | http://purl.uniprot.org/core/author | "Uematsu S."xsd:string |
| http://purl.uniprot.org/citations/14556004 | http://purl.uniprot.org/core/author | "Uematsu S."xsd:string |
| http://purl.uniprot.org/citations/14556004 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14556004 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |