| http://purl.uniprot.org/citations/14556986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14556986 | http://www.w3.org/2000/01/rdf-schema#comment | "CD40, a member of the tumor necrosis factor receptor (TNFR) family, promotes IgM, IgG, and IgA antibody (Ab) synthesis in combination with a variety of cytokines. Another TNFR family member, CD27, causes B cells to differentiate into antibody-forming cells, with marginal effects on proliferation. In the present study, we examined whether anti-CD27 monoclonal antibody (mAb) modulates the antibody production induced by anti-CD40 mAb immobilized on L cells expressing FcgammaRII (CDw32) in the presence of IL-2 and/or IL-10. The anti-CD40 mAb substantially enhanced IgM, IgG, and IgA production in combination with IL-2 and IL-10, whereas anti-CD27 mAb augmented it only marginally, as assessed by enzyme-linked immunosorbent assay. The addition of anti-CD27 mAb enhanced the anti-CD40-mediated IgM, IgG, and IgA antibody production only when both IL-2 and IL-10 were present in the culture. The CD27-positive B cell compartment generated synergistic antibody responses in response to four different stimulants, anti-CD27/anti-CD40 mAb and cytokines IL-2/IL-10, whereas the CD27-negative B cell compartment failed to do so. Kinetic analysis showed that anti-CD40 might function in the early phase of B cell activation, while anti-CD27 mAb functioned in the late stage. The addition of CD27(-) to CD27(+) B cells in various ratios did not have any effect on the antibody production, suggesting that CD27(+) to CD27(-) B cell interaction does not occur in this system. Our findings suggest that a member of the TNFR family, CD27, cooperates with CD40 to induce efficient antibody production in combination with cytokines IL-2 and IL-10."xsd:string |
| http://purl.uniprot.org/citations/14556986 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0165-2478(03)00156-1"xsd:string |
| http://purl.uniprot.org/citations/14556986 | http://purl.uniprot.org/core/author | "Mizuguchi J."xsd:string |
| http://purl.uniprot.org/citations/14556986 | http://purl.uniprot.org/core/author | "Hirano T."xsd:string |
| http://purl.uniprot.org/citations/14556986 | http://purl.uniprot.org/core/author | "Shimo K."xsd:string |
| http://purl.uniprot.org/citations/14556986 | http://purl.uniprot.org/core/author | "Yonekubo I."xsd:string |
| http://purl.uniprot.org/citations/14556986 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14556986 | http://purl.uniprot.org/core/name | "Immunol Lett"xsd:string |
| http://purl.uniprot.org/citations/14556986 | http://purl.uniprot.org/core/pages | "251-257"xsd:string |
| http://purl.uniprot.org/citations/14556986 | http://purl.uniprot.org/core/title | "CD27 synergizes with CD40 to induce IgM, IgG, and IgA antibody responses of peripheral blood B cells in the presence of IL-2 and IL-10."xsd:string |
| http://purl.uniprot.org/citations/14556986 | http://purl.uniprot.org/core/volume | "89"xsd:string |
| http://purl.uniprot.org/citations/14556986 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14556986 |
| http://purl.uniprot.org/citations/14556986 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14556986 |
| http://purl.uniprot.org/uniprot/P26842#attribution-1261520ACF087798385DF2F5DEBA6BB4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14556986 |