| http://purl.uniprot.org/citations/14557245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14557245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14557245 | http://www.w3.org/2000/01/rdf-schema#comment | "APP-BP1, first identified as an amyloid precursor protein (APP) binding protein, is the regulatory subunit of the activating enzyme for the small ubiquitin-like protein NEDD8. We have shown that APP-BP1 drives the S-to M-phase transition in dividing cells, and causes apoptosis in neurons. We now demonstrate that APP-BP1 binds to the COOH-terminal 31 amino acids of APP (C31) and colocalizes with APP in a lipid-enriched fraction called lipid rafts. We show that coexpression of a peptide representing the domain of APP-BP1 that binds to APP, abolishes the ability of overexpressed APP or the V642I mutant of APP to cause neuronal apoptosis and DNA synthesis. A dominant negative mutant of the NEDD8 conjugating enzyme hUbc12, which participates in the ubiquitin-like pathway initiated by APP-BP1, blocks neuronal apoptosis caused by APP, APP(V642I), C31, or overexpression of APP-BP1. Neurons overexpressing APP or APP(V642I) show increased APP-BP1 protein levels in lipid rafts. A similar increase in APP-BP1 in lipid rafts is observed in the Alzheimer's disease brain hippocampus, but not in less-affected areas of Alzheimer's disease brain. This translocation of APP-BP1 to lipid rafts is accompanied by a change in the subcellular localization of the ubiquitin-like protein NEDD8, which is activated by APP-BP1."xsd:string |
| http://purl.uniprot.org/citations/14557245 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200304003"xsd:string |
| http://purl.uniprot.org/citations/14557245 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200304003"xsd:string |
| http://purl.uniprot.org/citations/14557245 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/14557245 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/14557245 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/14557245 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/14557245 | http://purl.uniprot.org/core/author | "Neve R.L."xsd:string |
| http://purl.uniprot.org/citations/14557245 | http://purl.uniprot.org/core/author | "Neve R.L."xsd:string |
| http://purl.uniprot.org/citations/14557245 | http://purl.uniprot.org/core/author | "McPhie D.L."xsd:string |
| http://purl.uniprot.org/citations/14557245 | http://purl.uniprot.org/core/author | "McPhie D.L."xsd:string |
| http://purl.uniprot.org/citations/14557245 | http://purl.uniprot.org/core/author | "Hassinger L."xsd:string |
| http://purl.uniprot.org/citations/14557245 | http://purl.uniprot.org/core/author | "Hassinger L."xsd:string |
| http://purl.uniprot.org/citations/14557245 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14557245 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14557245 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/14557245 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/14557245 | http://purl.uniprot.org/core/pages | "27-33"xsd:string |
| http://purl.uniprot.org/citations/14557245 | http://purl.uniprot.org/core/pages | "27-33"xsd:string |
| http://purl.uniprot.org/citations/14557245 | http://purl.uniprot.org/core/title | "APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain."xsd:string |
| http://purl.uniprot.org/citations/14557245 | http://purl.uniprot.org/core/title | "APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain."xsd:string |
| http://purl.uniprot.org/citations/14557245 | http://purl.uniprot.org/core/volume | "163"xsd:string |
| http://purl.uniprot.org/citations/14557245 | http://purl.uniprot.org/core/volume | "163"xsd:string |