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| http://purl.uniprot.org/citations/14561875 | http://www.w3.org/2000/01/rdf-schema#comment | "Neurofilament assembly requires at minimum the polymerization of neurofilament light chain (NF-L) with either neurofilament medium chain (NF-M) or neurofilament heavy chain (NF-H) subunits, but requirements for their axonal transport have long been controversial. Using a gene deletion approach, we generated mice containing only NF-L or NF-M. In vivo pulse radiolabeling analyses in retinal ganglion cell neurons revealed that NF-L alone is incapable of efficient transport, whereas nearly one-half of the normal level of NF-M is transported along optic axons in the absence of the other triplet subunits. Under these conditions, however, NF-M transport is completely abolished by deleting alpha-internexin. Our results strongly suggest that efficient neurofilament protein transport in vivo minimally requires hetero-oligomer formation. They also show that NF-M can partner with intermediate filament proteins other than the NF-H and NF-L subunits in neurons to support slow transport and possibly other functions of neuronal intermediate filaments."xsd:string |
| http://purl.uniprot.org/citations/14561875 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.23-28-09452.2003"xsd:string |
| http://purl.uniprot.org/citations/14561875 | http://purl.uniprot.org/core/author | "Kumar A."xsd:string |
| http://purl.uniprot.org/citations/14561875 | http://purl.uniprot.org/core/author | "Julien J.P."xsd:string |
| http://purl.uniprot.org/citations/14561875 | http://purl.uniprot.org/core/author | "Nixon R.A."xsd:string |
| http://purl.uniprot.org/citations/14561875 | http://purl.uniprot.org/core/author | "Rao M.V."xsd:string |
| http://purl.uniprot.org/citations/14561875 | http://purl.uniprot.org/core/author | "Yuan A."xsd:string |
| http://purl.uniprot.org/citations/14561875 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14561875 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/14561875 | http://purl.uniprot.org/core/pages | "9452-9458"xsd:string |
| http://purl.uniprot.org/citations/14561875 | http://purl.uniprot.org/core/title | "Neurofilament transport in vivo minimally requires hetero-oligomer formation."xsd:string |
| http://purl.uniprot.org/citations/14561875 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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