| http://purl.uniprot.org/citations/14562382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14562382 | http://www.w3.org/2000/01/rdf-schema#comment | "AimTo investigate the association between the polymorphism of HLA-DRB1, -DQA1 and -DQB1 alleles and viral hepatitis B.MethodsHLA-DRB1, -DQA1 and -DQB1 alleles in 54 patients with chronic hepatitis B, 30 patients with acute hepatitis B and 106 normal control subjects were analyzed by using the polymerase chain reaction/sequence specific primer (PCR/SSP) technique.ResultsThe allele frequency of HLA-DRB1*0301 in the chronic hepatitis B group was markedly higher than that in the normal control group (17.31% vs 5.67%), there was a significant correlation between them (chi2=12.3068, Pc=0.0074, RR=4.15). The allele frequency of HLA-DQA1*0501 in the chronic hepatitis B group was significantly higher than that in the normal control group (25.96% vs 13.68%), there was a significant correlation between them (chi2=9.2002, Pc=0.0157, RR=2.87). The allele frequency of HLA-DQB1*0301 in the chronic hepatitis B group was notably higher than that in the normal control group (35.58% vs 18.87%), there was a significant correlation between them (chi2=15.5938, Pc=0.0075, RR=4.07). The allele frequency of HLA-DRB1*1101/1104 in the chronic hepatitis B group was obviously lower than that in the normal control group (0.96% vs 13.33%), there was a significant correlation between them (chi2=11.9206, Pc=0.0145, RR=18.55). The allele frequency of HLA-DQA1*0301 in the chronic hepatitis B group was remarkably lower than that in the normal control group (14.42% vs 30%), there was a significant correlation between them (chi2=8.7396, Pc=0.0167, RR=0.35).ConclusionHLA-DRB1*0301, HLA-DQA1*0501 and HLA-DQB1*0301 are closely related with susceptibility to chronic hepatitis B, and HLA-DRB1*1101/1104 and HLA-DQA1*0301 are closely related with resistance to chronic hepatitis B. These findings suggest that host HLA class II gene is an important factor determining the outcome of HBV infection."xsd:string |
| http://purl.uniprot.org/citations/14562382 | http://purl.org/dc/terms/identifier | "doi:10.3748/wjg.v9.i10.2221"xsd:string |
| http://purl.uniprot.org/citations/14562382 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/14562382 | http://purl.uniprot.org/core/author | "Wang Y.M."xsd:string |
| http://purl.uniprot.org/citations/14562382 | http://purl.uniprot.org/core/author | "Liu T.H."xsd:string |
| http://purl.uniprot.org/citations/14562382 | http://purl.uniprot.org/core/author | "Jiang Y.G."xsd:string |
| http://purl.uniprot.org/citations/14562382 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14562382 | http://purl.uniprot.org/core/name | "World J Gastroenterol"xsd:string |
| http://purl.uniprot.org/citations/14562382 | http://purl.uniprot.org/core/pages | "2221-2225"xsd:string |
| http://purl.uniprot.org/citations/14562382 | http://purl.uniprot.org/core/title | "Association between HLA class II gene and susceptibility or resistance to chronic hepatitis B."xsd:string |
| http://purl.uniprot.org/citations/14562382 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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