| http://purl.uniprot.org/citations/14565976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14565976 | http://www.w3.org/2000/01/rdf-schema#comment | "The microtubule-severing protein complex katanin is required for a variety of important microtubule-base morphological changes in both animals and plants. Caenorhabditis elegans katanin is encoded by the mei-1 and mei-2 genes and is required for oocyte meiotic spindle formation and must be inactivated before the first mitotic cleavage. We identified a mutation, sb26, in the tbb-2 beta-tubulin gene that partially inhibits MEI-1/MEI-2 activity: sb26 rescues lethality caused by ectopic MEI-1/MEI-2 expression during mitosis, and sb26 increases meiotic defects in a genetic background where MEI-1/MEI-2 activity is lower than normal. sb26 does not interfere with MEI-1/MEI-2 microtubule localization, suggesting that this mutation likely interferes with severing. Tubulin deletion alleles and RNA-mediated interference revealed that TBB-2 and the other germline enriched beta-tubulin isotype, TBB-1, are redundant for embryonic viability. However, limiting MEI-1/MEI-2 activity in these experiments revealed that MEI-1/MEI-2 preferentially interacts with TBB-2-containing microtubules. Our results demonstrate that these two superficially redundant beta-tubulin isotypes have functionally distinct roles in vivo."xsd:string |
| http://purl.uniprot.org/citations/14565976 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e03-06-0418"xsd:string |
| http://purl.uniprot.org/citations/14565976 | http://purl.uniprot.org/core/author | "Lu C."xsd:string |
| http://purl.uniprot.org/citations/14565976 | http://purl.uniprot.org/core/author | "Srayko M."xsd:string |
| http://purl.uniprot.org/citations/14565976 | http://purl.uniprot.org/core/author | "Mains P.E."xsd:string |
| http://purl.uniprot.org/citations/14565976 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14565976 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/14565976 | http://purl.uniprot.org/core/pages | "142-150"xsd:string |
| http://purl.uniprot.org/citations/14565976 | http://purl.uniprot.org/core/title | "The Caenorhabditis elegans microtubule-severing complex MEI-1/MEI-2 katanin interacts differently with two superficially redundant beta-tubulin isotypes."xsd:string |
| http://purl.uniprot.org/citations/14565976 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/14565976 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14565976 |
| http://purl.uniprot.org/citations/14565976 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14565976 |
| http://purl.uniprot.org/uniprot/P52275#attribution-F34ACDA5C602BDB79B837C86E11737B4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14565976 |
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| http://purl.uniprot.org/uniprot/#_O17921-mappedCitation-14565976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14565976 |
| http://purl.uniprot.org/uniprot/O17921 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14565976 |
| http://purl.uniprot.org/uniprot/P52275 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14565976 |